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Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs Melody Petersen See book keywords and concepts

The staff at the sand-colored brick medical center in Storm Lake, a town of twenty thousand people nestled among the cornfields of northwestern Iowa, had invited the public to learn about insomnia from Rebecca Hillmer, a sales rep for sanofi-aventis, a French drug company with extensive and expanding operations in the United States. The women who had come to lunch and learn did not look like the type that might be losing sleep by spending too much time at Malarky's, the purple-painted place for food and spirits just down the street.

Bottom Line's Health Breakthroughs 2007 Bottom Line Health See book keywords and concepts

According to sanofi-aventis, the most common side effects of Ambien include daytime drowsiness, dizziness and coordination difficulties. Many of these side effects can be avoided by taking the proper dose and avoiding alcohol. . . To get a good night's sleep, visit the Ameri-— can Academy of Sleep Medicine Web site at www.aasmnet.org/pdj7insomnia.pdf Medications to Help You Get a Good Night's Sleep Michael Thorpy, MD, director, Sleep-Wake Disorders Center, Montefiore Medical Center, and associate professor of neurology, Albert Einstein College of Medicine, both in Bronx, NY.

Funding for the trial was provided by the makers and distributors of Plavix, sanofi-aventis and Bristol-Myers Squibb. . , You can learn more about clopidogrel by — visiting the US National Library of Medicine's MedlinePlus Web site at www.medlineplus. gov. Click on "Drugs & Supplements." Should You Be Taking Aspirin? Anew study suggests that some people who are age 70 and older may be better off not using aspirin to protect themselves against cardiovascular disease. Theoretical calculations show that aspirin therapy could cause 57% more life-threatening hemorrhages in this age group.

Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer Shannon Brownlee See book keywords and concepts

Together, Sepracor; King Pharmaceuticals, which makes Sonata; and sanofi-aventis, the maker of Ambien, provide about a third of the sleep foundation's $3.6 million annual budget. In addition, Sepracor was a $250,000 platinum sponsor of the foundation's 200c poll; another $300,000 grant from the company went toward a series of "Sleep Medicine i ne rer suauer i i y 1 Alerts," brochures to educate doctors, who, according to Gelula, don't treat insomnia adequately because they "don't think sleeplessness is a sickness." But is it?

Big Pharma: Exposing the Global Healthcare Agenda Jacky Law See book keywords and concepts

Since then, of course, Pfizer has acquired another major player in Pharmacia, and Sanofi-Synthelabo taken over Aventis to create a major French force in the global industry, sanofi-aventis. All this corporate restructuring among the A-list players was mirrored every step of the way down the so-called value chain. A similar dynamic can be seen in the deals that took place in pharma's hinterland, at the level below pharma, where companies have also been taking their partners so they can dance along to pharma's new tune.

The relatively new European drugs conglomerate, sanofi-aventis, for example, is developing an obesity drug known generically as rimonabant that exploits knowledge of the 'munchies', a side effect of the recreational drug, cannabis. The modus operandi is to stunt activity of the canniboid receptors, thus reducing appetite. Such receptors are found throughout the body, including in the fat cells, and so far, the trial results have been encouraging. 'Data available so far have shown that the product is effective,' said pharmaceutical journalist Ailis Kane in January 2004.

Data on the first inhaled insulin product, Exubera (produced by a partnership between Pfizer of the US, sanofi-aventis of Europe and drug delivery company Nektar Therapeutics), was submitted in the US in March 2005. Whatever happens in the marketplace, however, doesn't detract from the fact that perfect insulin delivery is not an easy goal. Companies compete for benefits that become increasingly marginal. Most of the novel insulins in development are appealing because they act fast. But it is thought most patients will still need a conventional long-acting insulin injection in the morning.

Ketek drug scandal reveals pattern of scientific fraud at the FDA Mike Adams, the Health Ranger See article keywords and concepts

One FDA document concluded that sanofi-aventis hid safety dangers from the FDA -- dangers the FDA later discovered on its own. One FDA safety scientist, Dr. Cooper, wrote, “I tried to argue that given Aventis’s track record in which they have proven themselves to be nontrustworthy that we have to consider the possibility that they are intentionally doing a poor job of collecting the postmarketing data to protect their drug sales.” Dr. David Graham added, “For F.D.A.

Best Choices From the People's Pharmacy Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts

The manufacturer, sanofi-aventis, is being especially careful to downplay the cosmetic weight-reducing potential of Acomplia. Instead, they are highlighting other benefits, such as the improvement of lipid profiles. In three large clinical trials, Acomplia resulted in promising metabolic improvements.840,841'842 Good HDL cholesterol rose and bad triglycerides dropped. Insulin efficiency improved and blood sugar levels came down. The positive changes were twice what researchers would have anticipated from weight loss alone.

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