Mark Sircus
See book keywords and concepts |
 Tamiflu was actually developed by Gilead, which then gave roche Laboratories (www.roche.com) the exclusive rights to market and sell this drug.9 Trust in our government's medical officials is in short supply.
References
1 Bird Flu infecting Vietnamese Girl found Resistant to Primary Drug
(See: http://www.indystar.com/apps/pbcs.dll/article?AID=/20051015/ NEWS01/510150466)
2 Campbell's recommendation: Begin increasing the amount of vitamin C that you take each day to very high levels, spread over the course of the day, in divided doses taken with meals. |
Thomson Healthcare, Inc.
See book keywords and concepts |
 Product Information: Solatene® (beta-carotene). roche Laboratories, Nutley, NJ, 1996.
Product Information: Xenical® (orlistat). roche Laboratories Inc, Nutley, NJ, 1999.
Rautalahti MT, Virtamo JRK, Taylor PR et al: The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer; 86:37-42. 1999
Romney SL, Ho GYF, Palan PR et al: Effects of betacarotene and other factors on outcome of cervical dysplasia and human papillomavirus infection. Gynecol Oncol; 65:483-492. |
Melody Petersen
See book keywords and concepts |
 For example, the drug company roche created a program for overweight patients who were prescribed Xenical, its weight loss drug. The company asked doctors in Iowa and throughout the country to give their patients starter kits for its Xenicare program. roche asked these patients thirty personal questions, logged the information into its sophisticated database, and then used it to act like a coach or well-wisher to the person. The company sent holiday cards and congratulatory notes as the weeks passed and the patient continued taking the pills. |
Mark Sircus
See book keywords and concepts |
| Tamiflu was actually developed by Gilead, which then gave roche Laboratories (www.roche.com) the exclusive rights to market and sell this drug.9 Trust in our government's medical officials is in short supply.
References
1 Bird Flu infecting Vietnamese Girl found Resistant to Primary Drug
(See: http://www.indystar.com/apps/pbcs.dll/article?AID=/20051015/ NEWS01/510150466)
2 Campbell's recommendation: Begin increasing the amount of vitamin C that you take each day to very high levels, spread over the course of the day, in divided doses taken with meals. |
Ray Moynihan and Alan Cassels
See book keywords and concepts |
 As it turned out, roche couldn't even find the small number of social phobia patients needed to enroll in clinical trials of the company's drug, and the clumsy PR campaign was quietly abandoned.
Roche's plain-talking managing director in Australia, Fred Nadjarian, would later claim to have been "taken in" by estimates given to him by his marketing staff of how widespread the condition was supposed to be. "I thought there might be a big market," says Nadjarian, "but when we tried to recruit [for the trials] we just weren't able to. |
Dr. Steve Blake
See book keywords and concepts |
 The Most Popular Supplement
The Swiss pharmaceutical company Hoffman-La roche was the first to mass-produce vitamin C. Today, many thousands of tons of ascorbic acid are produced synthetically from glucose. The glucose is often derived from corn syrup.
Many consumers believe that vitamin C is beneficial, as about 30 percent of the U.S. adult population takes supplemental vitamin C. Currently, vitamin C is the most widely used vitamin supplement in the world.
Vitamin C is also used extensively to preserve food. |
Andreas Moritz
See book keywords and concepts |
 This is what the disclaimers say: "At present there is no recognized standard for establishing the presence or absence of HIV-1 antibody in human blood," or "The AMPLICOR HIV-1 MONITOR [Viral Load] test is not intended to be used as a screening test for HIV or as a diagnostic test to confirm the presence of HIV infection," or "Do not use this kit as the sole basis of diagnosis of HIV-1 infection" (Abbott Laboratories HIV Test, roche Viral Load Test and Epitope, Inc. Western Blot Test, respectively). |
Charles Barber
See book keywords and concepts |
 Leo Sternbach of Hoffman-La roche, Inc., Valium was one of the benzodiazepines, quick-acting antianxiety drugs which are, in effect, minor tranquilizers. Sternbach, who died in 2005 at the age of ninety-seven, was a kind of genius pharmacologist who also invented the sleeping pill Dalmane, the antiseizure medication Klonopin, and Arfonad, which limits bleeding during brain surgery. He held 241 drug patents by the end of his career.15 Far and away his most famous creation, though, was Valium—which he tested on himself only to discover that it made him depressed. |
Jacky Law
See book keywords and concepts |
 In the case of Roche's obesity drug Xenical, for example, NICE'S independent review estimated a CQG of £46,000 ($82,800). Translated, this represents a cost to the NHS of £46,000 a year to bring the patient's quality of life up to that of someone who was not obese -which would be cheap if it actually delivered on its promise, but that is not the point. roche, meanwhile, had arrived at a CQG of just £10,000 ($18,000).
Where the Alzheimer's drugs were concerned, the discrepancies were greater. |
Ralph W. Moss, Ph.D.
See book keywords and concepts |
 Merck Sharp & Dohme
ICI Pharma
Hoffmann La roche Adria
Hoffmann La roche Schering Plough Lederle, div. of Amer.
Cyanamid Cetus
Lederle, div. of Amer. Cyanamid
Bristol-Myers
Miles
Burroughs Wellcome Hoffmann La roche Burroughs Wellcome
Bristol-Myers
Bristol-Myers
Upjohn
Bristol-Myers
Pharmacia
Squibb
Table i (continued)
Trade Name
Common Name
Marketing Company
22. Matulane procarbazine
Hoffman La Roche
23. Mutamycin mitomycin
Bristol-Myers
24. Myleran busulfan
Burroughs Wellcome
25. Neosar cyclophosphamide
Adria
26. Platinol cis-platin
Bristol-Myers
27. |
Joerg Gruenwald, Ph.D.
See book keywords and concepts |
| Apotheker-Dienst roche 3:51-55.
Ernst E, (1959) St. John's Wort, an anti-depressant? A systematic, criteria-based overview. Phytomedicine 2:67-71.
Freytag WE, (1984) Dtsch Apoth Ztg 124(46):2383.
Giese AC, (1980) Hypericism. Photochem Photobiol Rev 5:229-255.
Hansel R, Keller K, Rimpler H, Schneider G, (Hrsg.), (1993) Hagers Handbuch der Pharmazeutischen Praxis, 5. Auflage, Drogen E-O. Springer Verlag, Berlin Heidelberg New York, S 268-292.
Hansgen KD, Vesper J, (1996) Antidepressive Wirksamkeit eines hochdosierten Hypericum-Extraktes. Munch Med Wschr 138:29-33. |
Marcia Angell, M.D.
See book keywords and concepts |
 A more recent example is the story of Roche's new HIV/AIDS drug, Fuzeon.20 Approved by the FDA in 2003, this drug is an important advance in AIDS treatment. According to a detailed story by the Wall Street Journal reporter Vanessa Fuhrmans, Fuzeon was discovered at Duke University, developed by a local biotechnology company, and only then acquired by roche. Despite its minimal contribution to early research and development, roche charges $20,000 a year for the drug— three times the price of most AIDS drugs. |
Ralph W. Moss, Ph.D.
See book keywords and concepts |
| Merck Sharp & Dohme
ICI Pharma
Hoffmann La roche Adria
Hoffmann La roche Schering Plough Lederle, div. of Amer.
Cyanamid Cetus
Lederle, div. of Amer. Cyanamid
Bristol-Myers
Miles
Burroughs Wellcome Hoffmann La roche Burroughs Wellcome
Bristol-Myers
Bristol-Myers
Upjohn
Bristol-Myers
Pharmacia
Squibb
Table i (continued)
Trade Name
Common Name
Marketing Company
22. Matulane procarbazine
Hoffman La Roche
23. Mutamycin mitomycin
Bristol-Myers
24. Myleran busulfan
Burroughs Wellcome
25. Neosar cyclophosphamide
Adria
26. Platinol cis-platin
Bristol-Myers
27. |
Greg Critser
See book keywords and concepts |
 His name was Gerry Mossinghoff. As Roche's Irv Lerner said, "He had all the tickets we could possibly want."
THE MAN IN THE MIDDLE: HOW PHARMA REINVENTED PAT I ENTS AND THE FDA
One of the things that Roche's Irv Lerner and Parke-Davis's Joe Williams liked about Gerry Mossinghoff — besides the former patent commissioner's simpatico view of patent law and his many useful governmental connections — was his vision of federal regulatory agencies. "About that, he was fresh," recalls Williams. |
Thomson Healthcare, Inc.
See book keywords and concepts |
| Product Information: Xenical® (orlistat). roche Laboratories Inc, Nutley, NJ, 1999.
Rautalahti MT, Virtamo JRK, Taylor PR et al: The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer; 86:37-42. 1999
Romney SL, Ho GYF, Palan PR et al: Effects of betacarotene and other factors on outcome of cervical dysplasia and human papillomavirus infection. Gynecol Oncol; 65:483-492. |
| Product Information: Soriatane (acitretin). roche Laboratores, Inc, Nutley, NJ; 4/2003.
Product Information: Zomig (zolmitriptan tablets). Zeneca Pharmaceuticals, Wilmington, DE; 1999.
Prost N. Tichadou L, Rodor F, et al: Interaction millcpcrtuis-venlafaxine (Article in French). Presse Med 29:1285-1286. 2000.
Quandt J, Schmidt U, Schenk N. Ambulante Behandlung leichter und mittelschwerer depressiver Verstimmungen. Allgemeinarzt 2:97-102. 1993.
Raffa RB. Screen of receptor and uptake-site activity of hypericin component of St. John's Wort reveals sigma receptor binding. |
The Life Extension Editorial Staff
See book keywords and concepts |
 Riboflavin 5-phosphate
2 mg
The Life Extension Foundation mandates that the
Vitamin B3 (niacinamide) (Roche)
100 mg ingredients in Life Extension Mix (and its oth
;r prod-
75 mg ucts) come only from pharmaceutical-grade suppliers,
Vitamin B3 (niacin) (Roche) such as roche and Nutrition 21. |
J. Douglas Bremner
See book keywords and concepts |
 Peter Schifferdecker, a doctor working for roche in Switzerland, wrote in a report for the FDA that Accutane "probably caused" depression, that doctors and patients should be warned, and that patients should be monitored for the development of the condition. As reported in USA Today, the company's U.S. marketing team "rewrote" his report because of concerns about its "impact on marketing strategy and product liability," removing the language about how Accutane could cause depression in some patients.
The FDA received an edited report that did not include these concerns about depression. |
Melody Petersen
See book keywords and concepts |
| Robinson, MD MPH has openly disclosed that s/he: has grant/research support from
Pfizer, Merck/Schering Plough, Hoffman La roche, Astra Zeneca, Wyeth Ayerst, Bristol Myers Squibb, Atherogenics, Proctor and Gamble, Glaxo-SmithKline, Sankyo and Abbott [sic]; and has resolved all relevant conflicts of interest." She did not explain how she had "resolved" all these conflicts.
In 2005 Dr. Robinson also disclosed that Pfizer was paying her not only to do research but also as a speaker and a consultant. |
J. Douglas Bremner
See book keywords and concepts |
| In 2000 roche changed the package warning to include depression, psychosis, and suicide as possible side effects. It took the suicide in 2000, of a boy being treated with Accutane who was the son of U.S. Congressman Bart Stupak (D-Michigan), to get the attention of the FDA, which convened an advisory committee to discuss the relationship between Accutane and depression that same year. The committee concluded that "more research" was needed on the topic. |
| In 1986 roche changed the package insert to include information that some patients had reported becoming depressed on Accutane. As reported in USA Today on December 7, 2004 (Kevin McCoy, "Drug Maker Rebuffed Call to
Monitor Users"), however, as of 2004 the company's spokespersons still publicly denied that there was a "causal relationship" between Accutane and depression, meaning that depression spontaneously developed, unrelated to Accutane, but secondary to other causes. |
| Since its approval for the indication of cystic acne by the FDA in 1982, Accutane, manufactured by the Swiss-based company roche, has been prescribed for 2 million patients in the U.S. and more than 8 million patients worldwide.
Extremely effective in treating severe acne, Accutane quickly became very successful, bringing in more than a billion dollars a year in sales, the result, in part, of doctors who also started prescribing it for patients suffering from "treatment-resistant" acne or the "psychological consequences of acne. |
Melody Petersen
See book keywords and concepts |
| At the same time, roche Laboratories had offered physicians twelve hundred dollars for prescribing the antibiotic Rocephin to twenty patients, according to a letter written on corporate letterhead. And the drugmaker Sandoz was sending checks for a hundred dollars to physicians who agreed to read a two-page article on how its organ transplant drug Sandimmune could treat psoriasis, a skin disease. Sandimmune had not been approved to treat psoriasis. |
J. Douglas Bremner
See book keywords and concepts |
| However, after planning a study with roche, the acting head of FDA Drug Surveillance concluded in 2002 that such a study could not be blinded because patients would know from the side effects (like skin dryness) what they were on and that therefore the study should not be performed. At that time the FDA knew of 173 cases of suicide from its MedWatch Program. Assuming that 1% of cases get reported, that would mean 17,300 cases of suicide.
My study of the effects of Accutane on brain function using brain imaging was first presented in November 2004. |
| Roche pointed out that depression is so common in the general population that you can't pick out an increased signal over background noise. On the other hand, what is the probability of developing depression solely by chance during a four-month course of treatment? Although the prevalence of depression (meaning that it has occurred at some time in your life) is
16%, the actual incidence (developing new-onset depression) during any given year is only 1.6%.
Therefore, in the four-month period of an isotretinoin trial, about 0.5% of patients would spontaneously develop depression. |
Melody Petersen
See book keywords and concepts |
| The company asked doctors in Iowa and throughout the country to give their patients starter kits for its Xenicare program. roche asked these patients thirty personal questions, logged the information into its sophisticated database, and then used it to act like a coach or well-wisher to the person. The company sent holiday cards and congratulatory notes as the weeks passed and the patient continued taking the pills. |
Gary Null and Amy McDonald
See book keywords and concepts |
 Mou-sain-Bosc M; roche M; et al. Magnesium Research, 2006 March, 19(l):53-62.
This study concluded that behavioral improvement was achieved in PDD-Autism with the combination vitamin B6-magnesium.
Magnesium Profile in Autism. Strambi M; Longini M; et al. Biological Trace Element Research, 2006 February, 109(2):97-104.
The researchers found that children with autistic spectrum disorders had lower plasma concentrations of magnesium than normal subjects, leading them to conclude that dietary management is crucial.
Developmental Neurotoxicity of Industrial Chemicals. |
Mike Adams, the Health Ranger
See article keywords and concepts |
 Thailand Tamiflu manufacturer roche announces that Thailand and the Philippines are not bound by patent restrictions, and may make their own versions of the drug.
The Indonesian government begins random checks on birds in several areas, in concert with civilian tip-offs, to detect bird flu outbreaks early.
The Russian Ministry of Agriculture announces that only two villages, one in the Kurgen region and one in the Astrakhan region, are still infected by bird flu.
Nov. 30, 2005 – Regulatory bodies, such as the U.S. |
T. Colin Campbell, Ph.D. and Thomas M. Campbell II
See book keywords and concepts |
 Corporate members include Coca-Cola, Taco Bell, Burger King, Nestle, Pfizer and roche Vitamins.9 Some drug companies sponsored the report directly, in addition to their support through the International Life Sciences Institute. I don't recall private corporations providing financial support for the NAS expert panels that I served on.
It seems as if there is no end to this story. The chair of the FNB has been an important consultant to several major dairy-related companies (e.g. |
Greg Critser
See book keywords and concepts |
| THE MAN IN THE MIDDLE: HOW PHARMA REINVENTED PAT I ENTS AND THE FDA
One of the things that Roche's Irv Lerner and Parke-Davis's Joe Williams liked about Gerry Mossinghoff — besides the former patent commissioner's simpatico view of patent law and his many useful governmental connections — was his vision of federal regulatory agencies. "About that, he was fresh," recalls Williams. Unlike Lew Engman, who saw in the regulatory agencies some kind of compact between the public and its leaders, Gerry Mossinghoff discerned unfulfilled commercial promise. Period. |
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