Mike Adams, the Health Ranger See article keywords and concepts | As we reported in a previous NewsTarget article on Paxil:
Researchers from Cardiff University in Britain and the Cochrane Centre examined data on paxil -- or its generic form, paroxetine -- from GlaxoSmithKline, legal cases and emails from nearly 1,400 patients who responded to a British TV program on antidepressants. The researchers found that 60 out of 9,219 people taking paxil -- 0.65 percent -- experienced a "hostility event," compared to 20 out of 6,455 patients taking placebo, or 0.31 percent. | Peter Rost See book keywords and concepts | In 2003, the company had to sign a corporate integrity agreement and pay a civil fine of $88 million for overcharging Medicaid in a False Claims Act case involving its anti-depressant paxil and the nasal-allergy spray Flonase.20
The following year, the New York State Attorney General, Eliot Spitzer, sued GlaxoSmithKline over unpublished studies showing lack of efficacy of paxil in children; Spitzer claimed that the company withheld information from doctors about the negative results of clinical trials it conducted on the use of paxil in children. | Bottom Line Health See book keywords and concepts | | Example: Formerly, paxil was one of many popular antidepressants on the market, but in the past five years, its manufacturer, GlaxoSmith-Kline, took a rare psychiatric condition known as social anxiety disorder and helped transform it into an often-diagnosed condition for which paxil is the cure.
•Who is the primary target for this kind of advertising? Every segment of the population is targeted.
Women are told that they should take medication for "illnesses" such as menopause and premenstrual syndrome, which actually are natural cyclical changes. | Phyllis A. Balch, CNC See book keywords and concepts | The effectiveness of paxil in long-term treatment of GAD (greater than 8 weeks) was not evaluated, nor was paxil studied in children and adolescents with GAD.
Caution: paxil should not be used in children and adolescents for the treatment of major depressive disorder. Antidepressants in adults and children should be used with caution. Never discontinue use of antidepressants without first consulting a physician.
Q Steroid drugs and oral contraceptives may cause serotonin levels in the brain to drop. | Bottom Line Health See book keywords and concepts | | Example: Formerly, paxil was one of many popular antidepressants on the market, but in the past five years, its manufacturer, GlaxoSmith-Kline, took a rare psychiatric condition known as social anxiety disorder and helped transform it into an often-diagnosed condition for which paxil is the cure.
•Who is the primary target for this kind of advertising? Every segment of the population is targeted.
Women are told that they should take medication for "illnesses" such as menopause and premenstrual syndrome, which actually are natural cyclical changes. | Phyllis A. Balch, CNC See book keywords and concepts | The effectiveness of paxil in long-term treatment of GAD (greater than 8 weeks) was not evaluated, nor was paxil studied in children and adolescents with GAD.
Caution: paxil should not be used in children and adolescents for the treatment of major depressive disorder. Antidepressants in adults and children should be used with caution. Never discontinue use of antidepressants without first consulting a physician.
Q Steroid drugs and oral contraceptives may cause serotonin levels in the brain to drop. | Charles Barber See book keywords and concepts | With little data and with pressure from managed-care companies reluctant to approve psychotherapy, which they feel is more expensive, doctors have taken it upon themselves to dole out these drugs to patients whose heads are swimming with the latest paxil ad on TV.
It is important to note, however, that much of the overprescribing is more well-intentioned, or at least naive or indifferent to the possible consequences, than conspiratorial. | | Some of these medications had been around since the 1950s and 1960s—mood stabilizers like lithium, antipsychotics such as Haldol and Thorazine—while others, at the time, were brand-new, with strange and exotic names like Prozac, paxil, and Zoloft. Each year over the course of the 1990s, new psychiatric medications were introduced and consumed en masse by my clients. Some of these new medications arrived with great fanfare and extremely high expectations. | Marshall Editions See book keywords and concepts | A category of drugs called tricyclic antidepressants can be used. paxil, a newer antidepressant, is also used to treat neuralgia. A class of drugs called anti-eleptics, which includes carbamazepine (Tegretol®), gabapentin (Neurontin®), topiramate (Topamax®), and lamotrigine (Lamictal®) are often prescribed. Analgesic pain-relieving drugs may be used as well. Tramadol, morphine, and oxycodone are sometimes needed to treat the serious pain of neuralgia. Topical anesthetics such as a lidocaine patch can also ease symptoms. | Charles Barber See book keywords and concepts | Each year more and more Americans were taking psychiatric medications, particularly the SSRI (selective serotonin reuptake inhibitor) antidepressants like Zoloft, paxil, and Prozac.
What started as a drip developed into a stream, a river, and then a torrent. Introduced to the market in 1988, Prozac appeared on the cover of Newsweek in 1990 ("A Breakthrough Drug for Depression"); was the subject of a best-selling and extremely influential book, Peter Kramer's Listening to Prozac in 1993; graced, again, in 1994 the Newsweek cover, this time with even greater claims ("Shy? Forgetful? Anxious? | Bottom Line Health See book keywords and concepts | | However, in September 2005, the FDA issued a warning about possible birth defects in infants born to women who took paxil during their first trimester. A number of studies have also shown that approximately 20% to 30% of babies born to women taking SSRIs in late pregnancy will develop "neonatal complications," which can include jitteriness and respiratory difficulties, Chambers says. In addition, a small study found that newborns whose mothers had used SSRIs during their pregnancy were at an increased risk of experiencing withdrawal symptoms. | Hyla Cass, M.D. See book keywords and concepts | Prozac Backlash: Overcoming the Dangers of Prozac, Zoloft, paxil, and Other Antidepressants with Safe, Effective Alternatives. New York, NY: Simon & Schuster, 2000.
Holford, Patrick. Optimum Nutrition for Your Mind. Laguna Beach, CA: Basic Health Publications, 2004.
Stoll, Andrew, Stoll, M.D. The Omega-3 Connection: The Groundbreaking Antidepression Diet and Brain Program. New York, NY: Free Press, 2002.
Websites
About.com—www.depression.about.com: Lots of great information on all aspects of depression and its treatment.
Cognitive Behavior Therapy (CBT) website—www.cognitivetherapy. | Bottom Line Health See book keywords and concepts | | In all, 14 of the infants who had PPHN had been exposed to selective serotonin reuptake inhibitors (SSRIs), a group of antidepressants that includes Celexa, paxil, Prozac and Zoloft, after the 20th week of gestation. Only six of the infants who did not have PPHN had been exposed to SSRIs.
That means that PPHN "occurred approximately six times more frequently in women taking SSRIs," says Christina D. Chambers, lead author of the study and assistant professor of pediatrics at the University of California, San Diego. | | In October 2004, the FDA directed manufacturers of SSRIs, which include (citalopram) Celexa, (paroxetine) paxil, (fluoxetine) Prozac and Zoloft, to put a special "black-box" warning on the drugs' labels to alert health-care providers of an increased risk of suicidal thoughts and behaviors in children and teens who are using the medications.
In July 2005, the FDA issued a public health advisory saying that this same risk may also apply to adults taking SSRIs, after several studies pointed to that possibility.
. | Charles Barber See book keywords and concepts | The people of the town may not know it, but Winterset is just one outpost, if a particularly prolific and lucrative one, of an economic and cultural phenomenon that has been building steadily since the 1988 arrival of Prozac, followed later by its cousins Zoloft and paxil. The one in six people of Winterset who take SSRIs and other antidepressants represent just one minuscule piece—one nail perhaps, or a little screw—of a towering, looming structure that has been building and growing and enlarging inexorably and relentlessly over the course of the 1990s. | | To increase their appeal for these segments of the market, Prozac and paxil come in mint- and orange-flavored liquids, respectively, and Clomicalm is meatflavored. A Los Angeles veterinarian estimates that 5 percent of the cats and dogs in his practice are taking psychotropic agents for their behavior.18
• Zoloft's American sales—$3.1 billion in 2005—exceeded those of Tide detergent that same year.19-20
• The worldwide sales of one drug for schizophrenia, Zyprexa— $4.7 billion in 2006—were greater than the revenue generated by the Levi Strauss Co. |
Too Profitable to CureBrent Hoadley, Ph.D. See book keywords and concepts | | There have been hints for many years that antidepressants, such as paxil, when given to children, can cause serious side effects, including suicide, but the FDA delayed taking any action to prevent these drugs from being prescribed for children. Eventually, they required the manufacturers of ten antidepressant drugs to add further warnings to their labels, and proposed that closer monitoring would be needed for both adults and children. | Hyla Cass, M.D. See book keywords and concepts | Selective serotonin reuptake inhibitors (SSRIs): citalopram
(Celexa, Cipramil, Talohexane), escitalopram (Cipralex, Lexapro), fluoxetine (Fluctin, Fontex, Lovan, Prozac, Sarafem), paroxetine (Aropax, paxil, Seroxat), and sertraline (Apo-Sertral, Gladem, Lustral, Stimuloton, Serlift, Zoloft)
SSRIs are the most commonly prescribed class of antidepressants.
Action: SSRIs work by tricking the brain into thinking there are more serotonin neurotransmitters than there really are. | Jonny Bowden, Ph.D., C.N.S. See book keywords and concepts | Actually this is true for the majority of people, but in some less common cases it may take up to five weeks to work, about the same as a pharmaceutical antidepressant in the SSRI class, which includes Prozac, paxil, and Zoloft.)
A review of eleven research papers on SAMe, published in Clinical Investigative Medicine in June 2005, concluded that "there appears to be a role for SAMe in the treatment of major depression in adults." Note the qualifier "major. | Gerald E. Markle and Frances B. McCrea See book keywords and concepts | Paxil, which grossed $2.3 billion in sales. Yet another SSRI, Celexa, placed seventeenth in sales, grossing $1.5 billion. SSRIs were also third in prescription activity, 140 million in 2002, up 12.6% from 2001.
It is generally believed that SSRIs are effective in the treatment of depression. Prescriptions are easy to get and millions of Americans take them. But, in this book, we repeatedly ask the question: Do they work? That is, are SSRIs effective treatments for depression?
In the early 1990s, SSRIs were tested against so-called tricyclic antidepressants (TCA), the drugs they replaced. | Larry Trivieri, Jr. See book keywords and concepts | When Rupert explained the problem to his oncologist, he was put on paxil, an antidepressant. "Using paxil when you already have a libido problem is counterproductive," Dr. Borkin says. "Rupert didn't know that one of the side effects of paxil is loss of libido, so taking it only compounded his problem." Dr. Borkin, in consultation with Rupert's oncologist, took him off paxil, then began phase two of Rupert's treatment. This entailed dietary changes and gastrointestinal refortification, Neuro-Emotional Sensory Training (NEST), natural hormone replacement, exercise, and marriage counseling. | Ann Blake Tracy, Ph.D. See book keywords and concepts | | August, 2000: In the United Kingdom their version of the FDA called the MCA wrote asking GlaxoSmithKline to include the following warning in the paxil package insert even though as of July, 2001 that has not yet happened:
"Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with Seroxat, until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences. | | The widespread use of Prozac, Zoloft, paxil, etc. is not a statement of their safety or their effectiveness. Their popularity is a statement about the effectiveness of an infinite marketing budget and incredible advertising campaign! To prevent further tragedy this medical research must be addressed in headline news without delay rather than remain buried in seldom read medical research documents as has been the case in the past with other mind-altering medications, once thought to be safe, which were subsequently prohibited by law (LSD, PCP, Ecstasy, etc. | Charles Barber See book keywords and concepts | Williams claims that paxil cured his anxiety, and Bradshaw his depression.) Julie Krone, Hall of Fame jockey, has endorsed Zoloft. Picabo Street, gold medal skier, has written about her depression.
Prozac alone has inspired a theatrical play (Prozac Sisters) and a video game (Virtual Prozac)22 and has supplied the opening premise of a novel, Matthew Sharpe's The Sleeping Father. (The father takes too many antidepressants and goes into a coma.) There is a new magazine, bp (underwritten by Pfizer and Bristol-Myers Squibb), offering hope for people suffering from bipolar disorder. | Joseph Glenmullen, M.D. See book keywords and concepts | When I asked Juan why he had been anxious before going on paxil he explained it was because of marital tensions. Both Juan and his wife were teachers. Having taught for years in a suburban school system, they both had "tremendous job security" and a good combined income. They owned their own home and had a cottage in Maine where they went for their long summer vacations. Having the summer off was important to him and a big part of why he chose a teaching career. All year long he looked forward to spending more time with his wife and children. | Mike Adams, the Health Ranger See article keywords and concepts | The very next day, we published a report about the anti-depressant drug paxil doubling the risk of violent behavior. (See http://www.newstarget.com/020406.html ) In that article, I stated, "This finding helps explain why school shootings are almost always conducted by children who are taking antidepressants. We also know that SSRIs cause children to disconnect from reality. When you combine that with a propensity for violence, you create a dangerous recipe for school shootings and other adolescent violence. | Mike Adams, the Health Ranger See article keywords and concepts | The researchers found that 60 out of 9,219 people taking paxil -- 0.65 percent -- experienced a "hostility event," compared to 20 out of 6,455 patients taking placebo, or 0.31 percent.
In that same article, published in September, 2006, I stated, "This finding helps explain why school shootings are almost always conducted by children who are taking antidepressants. We also know that SSRIs cause children to disconnect from reality. When you combine that with a propensity for violence, you create a dangerous recipe for school shootings and other adolescent violence. |
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