Hyla Cass
See book keywords and concepts |  Valerian: 200-600 mg at bedtime
I have prescribed these in various combinations for my patients who were withdrawing from benzodiazepines or the newer sleeping pills such as ambien (Zolpidem). As far as ambien goes: despite claims of Ambien's being "not quite a benzodiazepine" and non-addictive, this has not been so in the many cases I've seen.
Benzodiazepines (and ambien) must be withdrawn very slowly under close medical supervision, sometimes over several months. | | Valerian: 200-600 mg at bedtime
I have prescribed these in various combinations for my patients who were withdrawing from benzodiazepines or the newer sleeping pills such as ambien (Zolpidem). As far as ambien goes: despite claims of Ambien's being "not quite a benzodiazepine" and non-addictive, this has not been so in the many cases I've seen.
Benzodiazepines (and ambien) must be withdrawn very slowly under close medical supervision, sometimes over several months. |
Charles Barber
See book keywords and concepts |  A series of new sleep aids, such as ambien CR, Lunesta, and Rozerem, have recently tried to move into trazodone's territory. Being new agents, ambien CR, Rozerem, and Lunesta are at the start of their patent lives and therefore lucrative years. Recently, several articles have been published in the professional journals that have been described as "trazodone-bashing." It turns out that the authors of these articles— university psychiatrists—have been paid by the makers of ambien, Rozerem, et al. |
Mehmet C. Oz., M.D. and Michael F. Roizen, M.D.
See book keywords and concepts |  Ambien or This long-acting prescription will give you less of a hangover than other drugs may, ambien CR but some docs feel it is addictive. The controlled-release (CR) version will give you a or Lunesta boost after four hours to avoid middle-of-the-night awakening. Lunesta works like or Rozerem ambien but is thought to be nonaddictive. Rozerem works like melatonin in our opinion, and it is nonaddictive.
Sonata This fast-acting prescription hypnotic drug is good if you wake up in the middle of the night, because its effect is quick and won't last all night. |
Hyla Cass, M.D.
See book keywords and concepts | | As far as ambien goes: despite claims of Ambien's being "not quite a benzodiazepine" and non-addictive, this has not been so in the many cases I've seen.
Benzodiazepines (and ambien) must be withdrawn very slowly under close medical supervision, sometimes over several months. Stopping these drugs suddenly can bring on seizures, severe anxiety, insomnia, nightmares, abdominal pain, palpitations, loss of balance, sweating and quite a long list of other symptoms.
CANCER CHEMOTHERAPY
Chemotherapy. Just the word is enough to bring up a wave of anxiety. |
J. Douglas Bremner
See book keywords and concepts |  Another serious side effect that patients taking ambien have experienced is sleepwalking. ambien increases slow-wave sleep, which has been associated with sleepwalking. On March 8, 2006, the New York Times reported several cases of people who got up, walked around the house, cooked, and even drove. Cases of people who have gotten out of bed after taking ambien (sometimes with a glass of wine), driven, and gotten into car accidents, with absolutely no memory of what happened, have also been reported. |
Hyla Cass
See book keywords and concepts | | As far as ambien goes: despite claims of Ambien's being "not quite a benzodiazepine" and non-addictive, this has not been so in the many cases I've seen.
Benzodiazepines (and ambien) must be withdrawn very slowly under close medical supervision, sometimes over several months. Stopping these drugs suddenly can bring on seizures, severe anxiety, insomnia, nightmares, abdominal pain, palpitations, loss of balance, sweating and quite a long list of other symptoms.
CANCER CHEMOTHERAPY
Chemotherapy. Just the word is enough to bring up a wave of anxiety. |
Charles Barber
See book keywords and concepts | | Being new agents, ambien CR, Rozerem, and Lunesta are at the start of their patent lives and therefore lucrative years. Recently, several articles have been published in the professional journals that have been described as "trazodone-bashing." It turns out that the authors of these articles— university psychiatrists—have been paid by the makers of ambien, Rozerem, et al. According to The New York Times, "a careful reading of these articles reveals a pattern of rhetorical techniques" to put Trazodone in a negative light and downplay its positives. |
Greg Critser
See book keywords and concepts |  Then, in 1993, the French company Sanofi-Synthelab had a breakthrough with a drug it called ambien. The drug acted on the GABA complex of neurotransmitters, which promote sleep by stopping brain cells from firing. ambien made a person sleep pretty well and did not seem to cause day-after sluggishness. Using statistics from the nonprofit National Sleep Foundation (NSF), Sanofi was able to make a convincing case that insomnia was an undertreated condition, with only about 40 percent of all sufferers getting help. ambien won FDA approval. |
J. Douglas Bremner
See book keywords and concepts | | National Institute for Clinical Evidence (NICE) showed no difference among the different Z drugs (Sonata, Lunesta, ambien, or Imovane) in efficacy, next-day impairment, or risk of withdrawal or dependence. In addition, there were no benefits in terms of efficacy or side effects when they were compared to benzodiazepines. Sonata has a much shorter half-life (1 hour) than ambien (2.5 hours) and Lunesta (6 hours), and is therefore promoted as being associated with less drowsiness the next day. | | Cases of people who have gotten out of bed after taking ambien (sometimes with a glass of wine), driven, and gotten into car accidents, with absolutely no memory of what happened, have also been reported. Some people have gotten up in the middle of the night, crashed their cars into parked cars, and then tried to drive away, with no memory of what happened (remember Patrick Kennedy?).
One man on a transatlantic flight took ambien with two glasses of wine. In his sleep, he tore off his clothes and threatened to kill himself and others. As a result, the plane had to make an emergency landing. |
Shannon Brownlee
See book keywords and concepts |  Instead of changing his headache medication or sending him back to the neurologist for reevaluation, the school doctor prescribed ambien, a sleeping pill, which in rare cases can trigger depression, agitation, and suicide. When the ambien left Justin feeling bleary and depressed, the doctor put him on an antidepressant, which can cause akathisia. Then she put him on another drug in the same class that has similar side effects.
Why wasn't the doctor alerted by Justin's agitation and worsening symptoms? |
Mike Adams, the Health Ranger
See article keywords and concepts |  Even though ambien is clearly far more dangerous than marijuana, you don't see people being arrested for taking ambien. You don't see our prisons packed top to bottom with people who possessed ambien. And you don't see doctors -- who sold the drug to patients -- charged with dealing drugs.
That's because when it comes to dangerous drugs, there's a clear double standard: All prescription drugs, no matter how dangerous to individual health or public safety, shall remain legal. All drugs that are not controlled by Big Pharma, on the other hand, shall be made illegal. |
Benjamin H. Natelson, M.D.
See book keywords and concepts |  Although the drug companies push their newest product, one does not work any better than the next. ambien will soon be available as a generic and provides the best overall effect of drugs in this group, so I prescribe it most often. Since the remaining drugs in this class are quite expensive and can also be habit-forming, my next choice is Rozerem, the melatonin-like drug I mentioned earlier, because it is the only one of the sleep-inducing drugs that is not habit-forming. |
Bottom Line Health
See book keywords and concepts | | In many of the reported cases, users had combined ambien with alcohol or other drugs, or had taken it too soon before a hazardous activity, such as driving. "People may also be exceeding the [recommended] dose," Thorpy says. "The usual dose is 5 or 10 milligrams [mg], but sometimes people will take 20 mg. That could be a factor."
The AASM recommends that consumers read the fine print on the package inserts that come with all prescription sleep medications, to familiarize themselves with the proper usage and any potential side effects. |
Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D.
See book keywords and concepts |  Doctors prescribed medications to help her cope—a litany of drugs that reads like a pharmacology manual: Zoloft, Depakote, Risperidol, Imipramine, Klonopin, BuSpar, Paxil, Trazodone, Ativan, and ambien. But the meds helped to bring about another problem. In a year and a half, the 5-foot, 10-inch Stephanie ballooned from "anorexic looking" to 215 pounds. |
Bottom Line Health
See book keywords and concepts | | There's little doubt in my mind that ambien can cause parasomnias.
I don't think it's common; I think, it's a very small minority of patients.
Michael H. Silber, MB, ChB
Sleepwalking occurs when the brain doesn't catch up with the body as it emerges into wakefulness. "These parasomnias are related to the amount of time people have been in fairly deep, slow-wave sleep," Thorpy says. "So, if a sleep agent makes you sleep more consistently, with less arousals, you're more likely to have more of these behaviors. | | Don't Lose Sleep Over ambien Reports
Donna Arand, PhD, clinical director, Kettering Sleep Disorders Center, Dayton, OH, and spokeswoman, American Academy of Sleep Medicine.
Michael H. Silber, MB, ChB, professor of neurology, Mayo Clinic College of Medicine, codirector, Mayo Sleep Disorders Center, Rochester, MN, and president, American Academy of Sleep Medicine.
Michael Thorpy, MD, director, Sleep-Wake Disorders Center, Montefiore Medical Center, and associate professor of neurology, Albert Einstein College of Medicine, both in Bronx, NY.
American Academy of Sleep Medicine. | | Experts speculate that the reason these parasomnias are seen in ambien users is related to the drug's half-life, or the amount of time the drug stays active in the brain. "It lingers [for] a shorter time than Lunesta and a longer time than Sonata," Silber says. "So, it may have something to do with that half-life—the fact that it stays around for three to five hours may be just the length that's needed to do what it does. But we're not entirely sure."
TAKE AS DIRECTED
One thing that experts are sure of is that Am-bien, like all drugs, must be taken as directed. |
Greg Critser
See book keywords and concepts | | The drug acted on the GABA complex of neurotransmitters, which promote sleep by stopping brain cells from firing. ambien made a person sleep pretty well and did not seem to cause day-after sluggishness. Using statistics from the nonprofit National Sleep Foundation (NSF), Sanofi was able to make a convincing case that insomnia was an undertreated condition, with only about 40 percent of all sufferers getting help. ambien won FDA approval. |
Bottom Line Health
See book keywords and concepts | | See the preceding article on page 107 for information on the recent controversy about ambien.)
Best if you: Have difficulty falling asleep and/ or tend to wake up in the middle of the night and are not able to fall back asleep. Take at bedtime.
•Zaleplon (Sonata) also works quickly, but only lasts for two to four hours.
Best if you: Wake up in the middle of the night and don't intend to get up for at least four hours. For example, take it at 4 am if your rising time is 8 am. It's also good if you just have trouble falling asleep but don't have trouble sleeping through the night. |
Hyla Cass, M.D.
See book keywords and concepts | | Benzodiazepines (and ambien) must be withdrawn very slowly under close medical supervision, sometimes over several months. Stopping these drugs suddenly can bring on seizures, severe anxiety, insomnia, nightmares, abdominal pain, palpitations, loss of balance, sweating and quite a long list of other symptoms.
CANCER CHEMOTHERAPY
Chemotherapy. Just the word is enough to bring up a wave of anxiety. When we think of chemo, we think of hair loss, vomiting, nausea, and an overall inability to keep up with the demands of life. |
Mehmet C. Oz., M.D. and Michael F. Roizen, M.D.
See book keywords and concepts | | Lunesta works like or Rozerem ambien but is thought to be nonaddictive. Rozerem works like melatonin in our opinion, and it is nonaddictive.
Sonata This fast-acting prescription hypnotic drug is good if you wake up in the middle of the night, because its effect is quick and won't last all night. It works to initiate your going back to sleep, but it will not keep you asleep.
Desyrel (trazodone)
You kick so much that Requip you're considering trying out for the Chicago Bears. |
Shannon Brownlee
See book keywords and concepts | | When the ambien left Justin feeling bleary and depressed, the doctor put him on an antidepressant, which can cause akathisia. Then she put him on another drug in the same class that has similar side effects.
Why wasn't the doctor alerted by Justin's agitation and worsening symptoms? Concerns that SSRIs might be dangerous for some patients had already surfaced by 1994, just four years after Prozac was approved. |
Hyla Cass
See book keywords and concepts | | Benzodiazepines (and ambien) must be withdrawn very slowly under close medical supervision, sometimes over several months. Stopping these drugs suddenly can bring on seizures, severe anxiety, insomnia, nightmares, abdominal pain, palpitations, loss of balance, sweating and quite a long list of other symptoms.
CANCER CHEMOTHERAPY
Chemotherapy. Just the word is enough to bring up a wave of anxiety. When we think of chemo, we think of hair loss, vomiting, nausea, and an overall inability to keep up with the demands of life. |
Mike Adams, the Health Ranger
See article keywords and concepts | | For some time now, a significant number of people taking ambien (zolbidem) have found themselves in a virtual "Twilight Zone" allegedly caused by the drug. A small case study of the unusual effects of the drug on six drivers has caused quite a stir among healthcare professionals and people who use the drug to help them sleep. According to Liddicoat, drivers under the influence of unusually high doses of ambien have crashed their cars and then had absolutely no memory of the accident. |
Shannon Brownlee
See book keywords and concepts | | The two existing sleep drugs, ambien and Sonata, shared a two-billion-dollar-a-year market between them. Corey Davis, an analyst with JP Morgan, predicted in the Wall Street Journal that sleep drug sales could hit six billion dollars by 2008. Lunesta, said Davis, "could do for the insomnia market what Prozac did for depression." Meanwhile, the company's chief financial officer told investors, "It's a drug you can take again and again and again. The sky's the limit. |
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