Jack Challem
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 For this reason, we recommend that supplements, typically in the form of vanadyl sulfate, be used cautiously or under your physician's guidance. If you're taking it on your own, dosages of vanadyl sulfate up to 1 mg (1,000 meg) daily should be completely safe. Your physician may recommend 5 to 25 mg daily.
Iodine. The official recommended daily amount of iodine is a minis-cule 150 meg, compared with an estimated daily dietary intake of 13.8 mg in Japan (which is almost a hundred times higher!). |
Robert Hass, M.S.
See book keywords and concepts |
 VANADYL SULFATE
Studies have shown that vanadyl sulfate and bis (maltolato) oxova-nadium (BMOV), a trace mineral, promote sugar metabolism that helps lower blood glucose levels. vanadyl sulfate and BMOV may activate insulin receptors and reduce the amount of fatty acids carried in the blood (triglycerides). Small oral doses of vanadyl sulfate and BMOV do not alter insulin sensitivity in nondiabetic people, but it does improve insulin sensitivity in liver and muscle cells in people with type 2 diabetes. |
Marshall Editions
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 Take 300-600 mg of alpha lipoic acid a day to improve insulin sensitivity and reduce the symptoms of diabetic neuropathy. vanadyl sulfate improves glucose tolerance; take 100-300 mg a day. Take 3 g of fish oils a day to support the nervous system and assist in proper insulin function. B-complex vitamins are involved in glucose metabolism, and should be taken at 50 mg a day. Biotin, taken at 7,000-15,000 meg a day, reduces the changes of diabetic neuropathies. This is a B vitamin so consider the amount included in your B-complex vitamin and adjust the dosage accordingly. |
Hyla Cass, M.D.
See book keywords and concepts |
 Dose: Take 10 mg of vanadyl sulfate (most common form) daily, yielding 2 mg of vanadium.
Magnesium
The American Diabetes Association reports that 25 percent of diabetics are magnesium deficient (although other figures place this much higher), and that supplementing with this mineral can improve blood sugar control. Green vegetables such as spinach are good sources of magnesium, because the center of the chlorophyll molecule (which gives green vegetables their color) contains magnesium. |
Jack Challem
See book keywords and concepts |
| If you're taking it on your own, dosages of vanadyl sulfate up to 1 mg (1,000 meg) daily should be completely safe. Your physician may recommend 5 to 25 mg daily.
Iodine. The official recommended daily amount of iodine is a minis-cule 150 meg, compared with an estimated daily dietary intake of 13.8 mg in Japan (which is almost a hundred times higher!). Because soil
SPECIFIC BRANDS OF SUPPLEMENTS WE LIKE
Trying to remember the large number of nutritional supplements, along with all sorts of health claims, can make shopping confusing. |
Gabriel Cousens
See book keywords and concepts |
 Clinical trials have found a significant decrease in insulin requirements in patients with insulin-dependent diabetes after vanadyl sulfate therapy. They have also noted a decrease in cholesterol levels for both IDDM and NIDDM. It has also been found to stimulate glucose uptake and metabolism that leads to glucose normalization. In some cases it helps to restore insulin production in diabetic rats.
Kelp and sea vegetables are good sources of vanadium. |
Robert Hass, M.S.
See book keywords and concepts |
| VANADYL SULFATE
Studies have shown that vanadyl sulfate and bis (maltolato) oxova-nadium (BMOV), a trace mineral, promote sugar metabolism that helps lower blood glucose levels. vanadyl sulfate and BMOV may activate insulin receptors and reduce the amount of fatty acids carried in the blood (triglycerides). Small oral doses of vanadyl sulfate and BMOV do not alter insulin sensitivity in nondiabetic people, but it does improve insulin sensitivity in liver and muscle cells in people with type 2 diabetes. |
Michael Friedman, ND
See book keywords and concepts |
 Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66.
132. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.J Clin Invest 1995;95:2501-09.
133. Reddi A, DeAngelis B, Frank O, et al. Biotin supplementation improves glucose and insulin tolerances in genetically diabetic KK mice. Life Sci 1988;42:1323-30.
134. Koutsikos D, Fourtounas C, Kapetanaki A, et al. |
| Treated subjects received 50 mg vanadyl sulfate twice daily for 4 weeks, followed by a 4-week placebo phase. Modest improvements in fasting glucose and hepatic insulin resistance followed the treatment period and were sustained throughout the placebo period.73
Halberstam el al provided 100 mg vanadyl sulfate daily for 3 weeks to moderately obese type 2 diabetic and non-diabetic subjects. They observed a decrease in fasting plasma glucose and a significant improvement in insulin sensitivity in the type 2 diabetic subjects; however, no change was observed in the obese non-diabetic subjects. |
| Measurement of fasting plasma glucose and insulin-mediated glucose disposal during pre- and post-treatment periods suggested a beneficial effect of vanadyl sulfate on improving both hepatic and peripheral insulin sensitivity. These effects were sustained for up to 2 weeks after the vanadyl sulfate was discontinued.132
Vitamins Biotin
In experimental models of type 2 diabetes, biotin lowered post-prandial glucose levels, improved insulin response to a glucose load, and decreased insulin resistance. |
Jonny Bowden, M.A., C.N.S.
See book keywords and concepts |
 B complex omega-3s GLA magnesium
•«0 to possibly alpha lipoic acid chromium high-dose biotin carnitine
CoQIO x(3) green tea (EGCG) ginseng
5-htp x (1) bitter orange glutamine neptune krill oil vanadyl sulfate x(2)
1. 5-HTP is one of the few supplements thai has been shown to have an effect on weight loss by itself
2. vanadyl sulfate is recommended only under a physician's supervision.
3. See discussion of CoQIO on page 195.
8 Complex
I put the majority of my clients on B vitamins. |
Hyla Cass
See book keywords and concepts |
| Dose: Take 10 mg of vanadyl sulfate (most common form) daily, yielding 2 mg of vanadium.
Magnesium
The American Diabetes Association reports that 25 percent of diabetics are magnesium deficient (although other figures place this much higher), and that supplementing with this mineral can improve blood sugar control. Green vegetables such as spinach are good sources of magnesium, because the center of the chlorophyll molecule (which gives green vegetables their color) contains magnesium. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
See book keywords and concepts |
| Cohen N, Halberstam M, Shlimovich P et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995; 95: 2501-2509
84. Halberstam M, Cohen N, Shlimovich P et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996; 45: 659-666
85. Fawcett JP, Farquhar SJ, Walker RJ et al. The effect of oral vanadyl sulfate on body composition and performance in weight-training athletes. Int J Sport Nutr 1996; 6: 382-390
86. Harland BF and Harden-Williams BA. |
Mark Stengler, N.D.
See book keywords and concepts |
 DOSAGE
Studies have used a form of vanadium that's combined with another substance to create vanadyl sulfate, which is an excellent form for absorption. The usual dose used in studies is 300 milligrams per day of vanadyl sulfate. With regard to elemental vanadium, up to 100 micrograms daily is thought to be safe.
WHAT ARE THE SIDE EFFECTS?
There is not a lot known about the side effects of vanadium and there have not been any long-term human studies to investigate adverse effects. Digestive upset was the main side effect in one human study where vanadyl sulfate was used. |
Schuyler W. Lininger, Jr. DC
See book keywords and concepts |
 Halberstam M, Cohen N, Schlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996; 45: 659-66.
98. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin dependent diabetes mellitus. Metabolism 1996; 45: 1130-35.
99. Aharon Y, Mevorach M, Shamoon H. vanadyl sulfate does not enhance insulin action in patients with type 1 diabetes. Diabetes Care 1998; 21: 2194 [letter].
100. Baskaran K, Ahmath BK, Shanmugasundaram KR, Shanmug-asundaram ERB. |
Phyllis A. Balch, CNC
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 A combination of chromium picolinate, vanadyl sulfate, and other vitamins and minerals that work synergistically to regulate blood sugar levels and correct deficiencies. Caution: If you have diabetes, consult with your physician before taking any supplement containing chromium.
Garlic (Kyolic from Wakunaga)
As directed on label.
Decreases and stabilizes blood sugar levels. Enhances immunity and improves circulation.
L-Carnitine
plus L-glutamine
plus taurine
500 mg twice daily, on an empty stomach. Take with water. Do not take with milk. |
| Use vanadyl sulfate form.
Vitamin B complex
plus extra biotin
and inositol
50 mg of each major B vitamin 3 times daily (amounts of individual vitamins in a complex will vary). Do not exceed 300 mg daily from all supplements. 50 mg daily.
50 mg daily.
The B vitamins work best when taken together.
Improves the metabolism of glucose.
Important for circulation and for prevention of atherosclerosis. |
Joseph E. Mario
See book keywords and concepts |
 Kal's Ultra V4+, vanadyl sulfate). After discontinuing use over 20 weeks animals retained normal glucose tolerance. For goiter; anemia; tooth decay, tuberculosis, and rheumatism.
CONSTRAINTS: Food processing. Competes with Chromiumforabsorption, take 3-4 hours apart.
DEFICIENCY SIGNS: Diabetes (works with Chromium).
VANADIUM SOURCES: Fish, seafoods, kelp, soy, black pepper, vegetable oils, olives; possible to inhale from air.
SUPER-TRACE MINERAL ELEMENTS In Alphabetic Order
•ALUMINUM SEE under heavy Metals in Chapter Seven CONDITION & CURES.
•ANTIMONY (Sb) Atomic #51. |
Jonny Bowden, M.A., C.N.S.
See book keywords and concepts |
| HTP is one of the few supplements thai has been shown to have an effect on weight loss by itself
2. vanadyl sulfate is recommended only under a physician's supervision.
3. See discussion of CoQIO on page 195.
8 Complex
I put the majority of my clients on B vitamins. Energizing for many people, B vitamins are necessary for metabolizing carbohydrates, fats, and proteins, and your need for them increases significantly when you are under stress. A lot of people just plain feel better on them. |
James F. Balch, M.D. and Mark Stengler, N.D.
See book keywords and concepts |
 Vanadium
Function: Blood-sugar balance, bone and teeth development Sources: Shellfish, mushrooms, black pepper, and buckwheat Optimal Intake: 50 mg (as vanadyl sulfate form)
Deficiency Signs: None known, but blood-sugar imbalances are suspected. Toxicity: Little is known, but very high amounts may lead to cramps and diarrhea. |
Earl Mindell, R.Ph., Ph.D.
See book keywords and concepts |
 Vanadyl Sulfate
In the words of my friend the body builder, vanadyl sulfate makes him feel "pumped." Vanadyl mimics the action of the hormone insulin, which regulates the metabolism of carbohydrate and protein, breaking them down into a form that can be utilized by the cells to make energy. Serious body builders swear that within two or three weeks of taking vanadyl sulfate they feel and see a real difference in the size and strength of their muscles. The problem with vanadyl is that it can cause a sudden drop in blood sugar, which can be dangerous. |
Robert Hass, M.S.
See book keywords and concepts |
| Small oral doses of vanadyl sulfate and BMOV do not alter insulin sensitivity in nondiabetic people, but it does improve insulin sensitivity in liver and muscle cells in people with type 2 diabetes. Two recent studies showed that after just 3-4 weeks of treatment with vanadyl sulfate (50 milligrams twice daily), people with insulin-resistant type 2 diabetes experienced improved insulin sensitivity. vanadyl sulfate at the dose used was well tolerated and resulted in modest reductions of fasting plasma glucose. |
Michael Friedman, ND
See book keywords and concepts |
| These effects were sustained for up to 2 weeks after the vanadyl sulfate was discontinued.132
Vitamins Biotin
In experimental models of type 2 diabetes, biotin lowered post-prandial glucose levels, improved insulin response to a glucose load, and decreased insulin resistance.133 Although biotin has not been evaluated in humans for its effect on insulin resistance, this vitamin has demonstrated an ability to improve glucose metabolism in humans on dialysis and with type 2 diabetes,134 thus warranting future investigation. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts |
 Over a six-week period, a small group of people with type 2 diabetes were given 75—300 mg of vanadyl sulfate per day.238 Only in the groups receiving 150 mg or 300 mg was glucose metabolism improved, fasting blood sugar decreased, and another marker for chronic high blood sugar reduced. At the 300 mg level, total cholesterol decreased, although not without an accompanying reduction in the protective HDL cholesterol. None of the amounts improved insulin sensitivity. |
Michael Friedman, ND
See book keywords and concepts |
| Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.J Clin Invest 1995;95:2501-09.
133. Reddi A, DeAngelis B, Frank O, et al. Biotin supplementation improves glucose and insulin tolerances in genetically diabetic KK mice. Life Sci 1988;42:1323-30.
134. Koutsikos D, Fourtounas C, Kapetanaki A, et al. Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. Ren Fail 1996;18:131-37.
135. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts |
| Although there was no evidence of toxicity after six weeks of vanadyl sulfate supplementation, gastrointestinal side effects were experienced by some of the participants taking 150 mg per day and by all of the participants taking 300 mg per day. The long-term safety of the large amounts of vanadium needed to help people with type 2 diabetes (typically 100 mg per day) remains unknown. Many doctors expect that amounts this high may prove to be unsafe in the long term. |
Michael Friedman, ND
See book keywords and concepts |
| Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-35.
74. Chen MD, Lin PY, Lin WH. Investigation of the relationships between zinc and obesity. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 1991;7:628-34. [Article in Japanese]
75. Donovan DS, Solomon CG, Seely EW, et al. Effect of sodium intake on insulin sensitivity. AmJ Physiol 1993;264:E730-E734.
76. Gomi T, Shibuya Y, SakuraiJ, et al. |
Joseph E. Mario
See book keywords and concepts |
| Country Life's Power PumppowderwithGlucose Polymers Fructose, Maltodextrin complex carbohydrates, amino acid Chromium chelate, vanadyl sulfate and Pyridoxine Alpha-Ketoglutarate/PAK for Insulin (receptors) and Creatine; 2.5 grams Creatine Monohydrate for strong muscles and ATP; 1000 mg. Glutamine for muscle protein and recovery; Citric acid; 750 mg. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
See book keywords and concepts |
| Vanadyl sulfate, a form of vanadium (page 594) that may have an insulin-like action, was given to weight-training athletes in a double-blind trial, using 225 meg per pound of body weight per day, but no effect on body composition was seen after 12 weeks, and effects on strength were inconsistent.100 The importance of other individual vitamins and minerals is discussed elsewhere in this section. |
Earl Mindell
See book keywords and concepts |
 Available in the form of vanadyl sulfate, the biologically active form of vanadium.
Usual dose is 10 mg. half an hour before working out.
Diabetics should check with their doctor for specific dosage.
Toxicity and Warning Signs of Excess:
Can easily be toxic if taken in synthetic form. (See section 334, "Cautions.")
Personal Advice:
This is not one of the minerals that needs to be supplemented. A good fish dinner will supply you with the vanadium you need.
There is a biologically active form of vanadium, vanadyl sulfate. |
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