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Adaptogens: Herbs for Strength, Stamina, and Stress Relief

David Winston, RH(AHG), and Steven Maimes
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Classic Texts The classic Chinese treatise on medicine, the huang Di Nei Cbing Su Wen (Yellow Emperor's Classic of Internal Medicine) is considered the most important Chinese medical text and the most ancient. The book's authorship is attributed to huang Di (known as the Yellow Emperor, he lived around 2600 BCE), but it actually was written by several authors over a long period of time—probably during the period from 475 to 225 BCE. It is commonly believed in China that huang Di used ginseng, one of the oldest recorded tonics.

PDR for Herbal Medicines, Fourth Edition

Thomson Healthcare, Inc.
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Chen HW & huang HC. Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. In: Br J Pharm 124(6):1029-1040, 1998. Charles V, Charles SX. The use and efficacy of Azadirachta indica ADR ("Neem") and Curcuma longa ("Turmeric") in scabies. A pilot study. In: Trop Geogr Med, 30:178-81, 1992. Dhar ML. et al Indian J Exp Biol 6:232, 1968. Donatus IA, SardJoko, Vermeulen NP. Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity lipid peroxidation and glutathione depletion in rat hepatocytes.

Earl Mindell's Supplement Bible: A Comprehensive Guide to Hundreds of NEW Natural Products that Will Help You Live Longer, Look Better, Stay Heathier, ... and Much More!

Earl Mindell, R.Ph., Ph.D.
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In fact, the Western drugs ephedrine and pseudoephedrine, which are commonly found in over-the-counter cold preparations, are compounds derived from ma huang. Ma huang is a "hot" or yang herb. In fact, it speeds up metabolism and is used in the West in some herbal weight-loss formulas. Although ma huang has been used safely in China for 4000 years, there have been reports of teens using it to get high. If taken in excess, ma huang can have an amphetamine-like effect, causing the heart to race and blood pressure to rise. This herb should definitely not be used by people with heart problems.

1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses

Marshall Editions
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TRADITIONAL CHINESE MEDICINE Herbs: Combine 15 g of Shen Di huang (Chinese foxglove), 12 g of Shan Zhu Yu (Asiatic cornelian cherry fruit), 15 g of Shan Yao (Chinese yam), 15 gof Fuling (poria), 12 gof Ze Xie (water plantain rhizome), 12 g of Dan Pi (cortex of tree peony root), 12 g of Di Gu Pi (cortex of wolfberry root), 12 g of Nan Sa Shen (glehnia root), and 5 g of Gan Cao (licorice). If hot flashes are accompanied by heavy sweating, add 12 g of Fu Xiao Mai (wheat), and 15 g of Bai Shao (white peony root). Place the herbs in a glass or ceramic pot and add 3 cups of water.

The Science of Flavonoids

Erich Grotewold
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Chen, W. F, huang, M. H, Tzang, C. H., Yang, M., and Wong, M. S., 2003, Inhibitory actions of genistein in human breast cancer (MCF-7) cells, Biochim Biophys Acta, 1638: 187-196. Chen, Y. C, Liang, Y. C, Lin-Shiau, S. Y., Ho, C. T., and Lin, J. K., 1999, Inhibition of TPA-induced protein kinase C and transcription activator protein-1 binding activities by theaflavin-3,3'-digallate from black tea in NIH3T3 cells, J Agric Food Chem, 47: 1416-1421. Cohen, D. R., and Curran, T.
Ma, W., huang, C, and Yang, C. S., 1997b, Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins, Cancer Res, 57: 4414-4419. Dwyer, J., 1995, Overview: dietary approaches for reducing cardiovascular disease risks, J Nutr, 125:656S-665S. Eberhardt, M. V., Lee, C. Y., and Liu, R. H, 2000, Antioxidant activity of fresh apples, Nature, 405:903-904. Elliott, A. J, Scheiber, S. A., Thomas, C, and Pardini, R. S., 1992, Inhibition of glutathione reductase by flavonoids.

PDR for Herbal Medicines

Joerg Gruenwald, Ph.D.
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Rauwald HW, huang DT, (1985) Phytochemistry 24(7):1557. Further information in: Hansel R, Keller K, Rimpler H, Schneider G (Hrsg.), Hagers Handbuch der Pharmazeutischen Praxis, 5. Aufl., Bde 4-6 (Drogen): Springer Verlag Berlin, Heidelberg, New York, 1992-1994. Tarragon See Artemisia Dracunculus Taumelloolch See Lolium Temulentum Taxus Baccata Yew DESCRIPTION Medicinal Parts: The medicinal parts are the fresh leaves, the branch twig tips, and the branches. Flower and Fruit: The flowers are inconspicuous and dioecious.

The Science of Flavonoids

Erich Grotewold
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Y, Ke, F. C, huang, C. J, Kandaswami, C, Lee, P. P., and Lee, M. T, 2004, Trans-inactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells, Biochem Pharmacol, 67: 2103-2114. Leeuwenburgh, C, Hardy, M. M, Hazen, S. L, Wagner, P, Oh-ishi, S, Steinbrecher, U. P, and Heinecke, J. W, 1997, Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima, J Biol Chem, 272: 1433-1436. Lepley, D. M, Li, B, Birt, D. F., and Pelling, J.
Apigenin inhibits protein kinase C (PKC) and MAPK (Kuo and Yang, 1995; huang et al., 1996). Quercetin is routinely used as an inhibitor of mammalian PIPK, phospholipase A2, phosphodiesterases, and PKC by binding to the catalytic domain (Levy et al., 1984; Graziani and Chayoth, 1977, 1979; Graziani et al, 1982, 1983; Tammela et al., 2004). Quercetin also inhibits Ca2+-dependent and phospholipid-dependent protein kinase activities (Gschwendt et al., 1983). Kaempferol inhibits mammalian monoamine oxidase/peroxidases, of which the IAA oxidase is a family member (Sloley et al., 2000).
Liang, Y. C, huang, Y. T., Tsai, S. H., Lin-Shiau, S. Y., Chen, C. F„ and Lin, J. K, 1999b, Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages, Carcinogenesis, 20: 1945-1952. Liang, Y. C, Lin-Shiau, S. Y., Chen, C. F, and Lin, J. K, 1999c, Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate, J Cell Biochem, 75: 1-12. Lichtenstein, A. H.
Phosphatidylinositol-3 kinase is necessary for 12-0-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation, J Biol Chem, 272:4187-4194. huang, C, Ma, W. Y., Young, M. R., Colburn, N., and Dong, Z., 1998, Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells, Proc Natl Acad Sci USA, 95: 156-161. Ishikawa, T., Suzukawa, M., Ito, T., Yoshida, H., Ayaori, M., Nishiwaki, M., Yonemura, A., Hara, Y., and Nakamura, H.

1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses

Marshall Editions
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Herbal footbath: Add 30 g of Ku Shen (sophora root), 30 g of huang Bai (phellodendron), 18 g of Ma Zhi Xian (dried purslane), 20 g of Cang Zhu (atractylodes rhizome), 30 g of Bai Xian Pi (dictamnus root bark) to 6 cups of fresh water in a ceramic herb cooking pot. Boil the herbs for five minutes. Turn down the heat and simmer for 30 minutes, then strain the herbs. You will get approximately 4 cups of liquid. Pour 2 cups into a pan, add hot water, and soak your feet in the herbal footbath for 20 minutes once a day before going to bed.
Herbal decoction: Combine 12 g of Di huang (Chinese foxglove), ž12 g of Bai Shao (white peony root), 10 g of Ye Ju Hua (wild chrysanthemum flower), 12 g of Gou Ji Zi (wolfberry), and 12 g of Gou ¦ Teng (stem and thorns of gambir vine) with 3 cups of water in a ceramic or glass pot. Bring the mixture to a boil and simmer for 30 minutes. Strain the liquid and drink 1 cup three times a day for three to five days. This formula nourishes the liver and kidneys, helping to promote energy flow in the eyes.

PDR for Herbal Medicines, Fourth Edition

Thomson Healthcare, Inc.
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Frankel EN, huang SW, Aeschbach R, Prior E. Antioxidant Activity of a Rosemary Extract and Its Constituents, Carnosic Acid, Carnosol, and Rosmarinic Acid, in Bulk Oil and Oil-in-Water Emulsion. J Agric Food Chem. 44 (1); 131-135. 1996 Ganeva Y, Tsankova E, Simova S, Apostolova B, Zaharieva E. Rofficerone: A New Triterpenoid from Rosmarinus officinalis. Planta Med. 59; 216-211. 1993 Giachetti D, Taddei E, Taddei I. Pharmacological Activity of Mentha piperita, Salvia officinalis and Rosmarinus officinalis Essences on Oddi's sphincter. Planta Med. 52; 543-544. 1986 Haraguchi H et al.

1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses

Marshall Editions
See book keywords and concepts
External herbal formula: Place 30 g each of Bu Gu Zhi (psoralea fruit), Jiang huang (turmeric rhizome), and Zi Cao (groomwell root) in a sealable container. Add 500 ml of rice wine, seal, and let the herbs soak for seven days. Apply the liquid to the areas of skin that lack color. Acupuncture: Acupuncture is effective for all types of vitiligo conditions. A long-term treatment is usually required, once a week for three to six months. Treatment can be combined with herbal formulas.

PDR for Herbal Medicines, Fourth Edition

Thomson Healthcare, Inc.
See book keywords and concepts
Vahedi K, Domigo V, Amerenco P et al: Ischaemic stroke in a sportsman who consumed MA huang extract and creatine monohydrate for body building. J Neurol Neurosurg Psychiatry; 68(1):112-113. 2000. Van Mieghem W, Stevens E & Cosemans J: Ephedrine-induced cardiopathy. BMJ; 1:816. 1978. Vukovich MD, Schoorman R, Heilman C, et al. Caffeine-herbal ephedra increases resting energy expenditure, heart rate and blood pressure. Clin Exp Pharmacol Physiol; 32(1-2): 47-53. 2005. Weinberger M, Bronsky E, Bensch GW et al: Interaction of ephedrine and theophylline. Clin Pharmacol Ther; 17:585-592. 1975.
Nadir A, Agrawal S, King PD et al: Acute hepatitis associated with the use of a Chinese herbal product, Ma huang. Am J Gastroenterol; 91:1436-1438. 1996. Nishikawa T, Kimura T, Taguchi N et al. Oral clonidine preanesthetic medication augments the pressor responses to intravenous ephedrine in awake or anesthetized patients. Anesthesiology; 74:705-710. 1991. Norregaard J, Jorgensen S, Mikkelsen K et al. The effect of ephedrine plus caffeine on smoking cessation and postcessation weight gain. Clin Pharmacol Ther; 60:679-686. 1996. Onuigbo M & Alikhan M.

The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why

Jonny Bowden, Ph.D., C.N.S.
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Liping huang, a geneticist at the ARS Western Human Nutrition Research Center at Davis, California, notes that "mild zinc deficiency may exist in the United States among otherwise healthy infants, toddlers, preschool children, pregnant and lac-tating women, and seniors." Vegetarians who avoid meat and dairy are also at risk for mild zinc deficiencies. Not Just a Man's Mineral Zinc has something of a reputation in the men's health magazines as a "guy's" nutrient, largely because it is critical for the production of both sperm and the male hormone testosterone.

PDR for Herbal Medicines, Fourth Edition

Thomson Healthcare, Inc.
See book keywords and concepts
Lin JK; Chen YC; huang YT; Lin-Shiau SY. Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J Cell Biochem Suppl;28-29:39-48. 1997. Lorenzo PS; Rubio MC; Medina JH; Adler-Graschinsky E. Involvement of monoamine oxidase and noradrenaline uptake in the positive chronotropic effects of apigenin in rat atria. Eur J Pharmacol Sep 26;312(2):203-7. 1996. Maiche AG, Grohn P, Maki-Hokkonen H, Effect of Chamomile cream and almond ointment on acute radiation skin reaction. Acta Oncol 30(3):395-396. 1991.
A randomized, double-blind cross-over study was designed to determine whether the consumption of an acute dose of caffeine and Ma huang increases resting energy expenditure (REE), heart rate (HR), and blood pressure (BP) over a period of 3 hours. A total of 8 healthy subjects took part in the study. The combination of caffeine and herbal ephedra at doses of 150 mg and 20 mg, respectively, resulted in significant elevation of REE, HR and BP. Although significant, the increase in energy expenditure was negligible in terms of weight loss (Vukovich et al, 2005).

The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants

Michael T. Murray, N.D.
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Ma huang refers to the stem and branch, whereas Ma Huanggen refers to the root and rhizome. Ma huang was used primarily in the treatment of the common cold, asthma, hay fever, bronchitis, edema, arthritis, fever, hypotension, and urticaria.1 Ma Huanggen's effect is believed to oppose that of the stem and branches. Its use was limited to the treatment of profuse night sweating.3 Western medicine's interest in ephedra began in 1923, with the demonstration that the isolated alkaloid ephedrine possessed a number of pharmacological effects.

Prescription for Natural Cures: A Self-Care Guide for Treating Health Problems with Natural Remedies Including Diet and Nutrition, Nutritional Supplements, Bodywork, and More

James F. Balch, M.D. and Mark Stengler, N.D.
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Huang Di Nei Jing, or The Yellow Emperor s Inner Classic, now almost two thousand years old, is one of the oldest medical texts still in use today. Scholars believe that it was compiled over a period of centuries. Written as a dialogue between the Yellow Emperor and Qi Bo, his leading minister, it is required reading for the serious student of Chinese medicine. Like the huang Di Nei Jing, the other weighty volumes that form the backbone of Chinese medical practice reflect many centuries of compilation and review.

The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why

Jonny Bowden, Ph.D., C.N.S.
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Chinese emperor Shih huang was reputed to have sent a fleet of ships to search for a mushroom called the "Elixir of Immortality." That mushroom? The reishi. Its special chemical makeup was thought to be a tonic for a long and healthy life. In traditional Chinese medicine, reishi is still considered to be among the highest class of tonics. Now we're finding out that they may have been on to something. One study at Cornell Medical College found that reishi reduced side effects during chemotherapy while improving the quality of life.

1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses

Marshall Editions
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Niu huang Shang Qin Wan: Take this patent Chinese herbal pill according to instructions for one week. If your condition does not improve, see a doctor. Acupuncture: This will reduce the infection and eliminate pain. You may see immediate relief after one or two treatments, but for acute pain you may need daily treatments. For chronic pain, you may need acupuncture once or twice a week for a few months.

The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide

Brigitte Mars, A.H.G.
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Ma translates as "astringent" or possibly "hemp" (in reference to the starlike stems of the plant), while huang translates as "yellow," in reference to the plant's color.

Adaptogens: Herbs for Strength, Stamina, and Stress Relief

David Winston, RH(AHG), and Steven Maimes
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A well-publicized example is the herb ephedra (ma huang), which has been inappropriately used for weight loss or as a stimulant. Serious adverse reactions, including death, have occurred, and in most cases, the people involved were foolishly taking two to four times the recommended dosage. Many herbs are useful and safe in small, appropriate doses, but as with any medication, overdoses can cause unwanted side effects, injuries, and if the statistics are correct, rare fatalities. General dosage information is provided in each monograph.
Li Gao, in the book huang Di Neijing Lingshu (Canon of Medicine of the Yellow Emperor: Miraculous Pivot) wrote that astragalus replenishes the three portions of the body cavity and reinforces the body's resistance to external evils (disease). Combining astragalus with licorice and ginseng, he stated, "forms a miraculous prescription for eliminating heat in the muscles and restlessness and irritation." A related species, A. floridus, is used in Tibetan medicine.
It is commonly believed in China that huang Di used ginseng, one of the oldest recorded tonics. Shennong is the legendary originator of Chinese herbal medicine, and the book named after him is known today as the Shennong Bencao Jing (the Shennong Herbal). This text is also known as the Herbal Classic of Shennong, and sometimes the Divine Husbandman's Classic of the Materia Medica. It is thought that Shennong lived from 2737 to 2697 BCE, nearly five thousand years ago; this is why it is common to hear that Chinese herbal medicine has a history of five thousand years.
Legendary emperor Shennong ruled during the San huang dynasty (3000-2700 BCE). Known as the Divine Farmer, he is credited with the invention of agriculture, wooden plows, Chinese herbal medicine, and markets. A version of his book, the Shennong Bencao Jing (the Shennong Herbal) is still in print today. This book is based on a much later version written by the Chinese physician Tao Hong-jing in the fifth or sixth century CE. The book states that licorice is used to balance the five viscera (organs) and six bowels.

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