Thomson Healthcare, Inc.
See book keywords and concepts |  GLUCOCORTICOIDS
Adonis
(Increases action of Adonis) Kombe' Seed
(Increases effects and side effects of herb) Licorice
(Licorice potentiates effect of glucocorticoids) Lily-of-the-Valley
(Increases the effect of Lily-of-the-Valley) Oleander
(Increased efficacy and side effects when given simultaneously with herb) Squill
(Increases effectiveness and side effects of herb) Strophanthus (Simultaneous administration with herb enhance both effects and side effects)
GLYBURIDE
Bitter Melon (Concurrent use may result in an increased risk of hypoglycemia)
Kudzu
(P. |
Bradley J. Willcox, M.D., D. Craig Willcox, Ph.D., Makoto Suzuki, M.D.
See book keywords and concepts |  The interesting thing about glucocorticoids is that they have a dual effect. For the short term, they improve memory and physical performance, but over the long term, high elevations of glucocorticoids cause decreased ability in both areas; they break down our stored carbohydrate, raise our blood sugar levels, and cause many of the age-related changes we see in overweight people.80 Consuming fewer calories helps produce the consistently right amount of glucocorticoidsjust enough to keep us sharp, but much less than we'd experience in a stressful situation. |
Bottom Line Health
See book keywords and concepts | | Stress and anxiety increase levels of glucocorticoids, hormones that damage the hippocampus, the part of the brain that controls memory.
Depression saps motivation and self-esteem and it can cause significant declines in memory. In patients who already have Alzheimer's symptoms, depression and stress can actually accelerate mental declines.
Know the signs: Insomnia, changes in appetite, increasing irritability or a loss of interest in daily activities can indicate clinically significant stress and/or depression. See a doctor or therapist right away. |
Thomson Healthcare, Inc.
See book keywords and concepts | | POTENTIAL INTERACTIONS
The simultaneous administration of quinidine, calcium salts, saluretics, laxatives and glucocorticoids enhance effects and side effects. overdosage
Nausea, vomiting, headache, stupor and cardiac arrhythmias could occur as side effects with parenteral administration of glycoside mixtures of the drug, particularly with overdoses. dosage
Mode of Administration: Communited drug, herb powder, and liquid preparations for internal use. | | POTENTIAL INTERACTIONS
The simultaneous administration of quinidine, digoxin, calcium salts, saluretics, laxatives, and glucocorticoids enhances effects and side effects of these drugs. overdosage
For symptoms of an acute poisoning and therapy, see Digitalis folium. The dangers of poisoning are relatively low with oral application, due to the poor absorbability of the glycosides. dosage
Mode of Administration: Comminuted herb, as well as galenic preparations for internal use; no longer considered safe because of the levels of toxins. | | POTENTIAL INTERACTIONS
Quinidine, Calcium Salts, Saluretics, Laxatives, or Glucocorticoids: Concurrent use may result in increases of both efficacy and side effects. overdosage
See Precautions and Adverse Reactions. dosage
How Supplied: Forms of commercial pharmaceutical preparations include solutions, coated tablets and compound preparations.
Dosage: No information is available.
Storage: Oleander should be stored where it is protected from dampness and light. literature
Begum S, Sultana R, Siddiqui BS. Triterpenoids from the Leaves of Nerium oleander. Phytochemistry 44 (2); 329-332. | | POTENTIAL INTERACTIONS
Quinidine, Calcium, Saluretics, Laxatives, and Extended Therapy with Glucocorticoids: Concurrent use may result in increased effectiveness and side effects of these substances.
Arrhythmogenic Substances (sympathomimetics, methylxan-thines, phosphodiesterase inhibitors, and quinidine): Concurrent use may result in an increased risk of cardiac arrhythmias. | | POTENTIAL INTERACTIONS
Simultaneous administration of quinidine, calcium salts, saluretics, laxatives, and glucocorticoids may enhance both effects and side effects. overdosage
Queasiness, vomiting, headache, stupor, disturbance of color vision and cardiac arrhythmias are the most likely consequences of overdosage, which is more likely to occur with parenteral administration of strophanthin-G or glycoside mixtures.
For a review of symptoms of an acute poisoning and therapy, see Digitalis folium. |
Paula Begoun and Bryan Barron
See book keywords and concepts |  Some concerns about hydroquinone's safety on skin have been expressed, but when it comes to topical application, the research indicates that negative reactions are minor or a result of using extremely high concentrations—or are caused by adulterated products in some countries that use glucocorticoids or mercury iodine. |
Joerg Gruenwald, Ph.D.
See book keywords and concepts | | Drug Interactions: Enhancement of efficacy, and thus also of side effects, with simultaneous administration of quinidine, calcium, saluretics, laxatives, and extended therapy with glucocorticoids.
OVERDOSAGE
For possible symptoms of overdose and treatment of poisonings see Digitalis folium.
DOSAGE
Mode of Administration: Comminuted herb and preparations thereof for internal use.
Daily Dosage: The average daily dose is 0.5 gm of standardized Adonis powder. The maximum single dose is 1.0 gm; maximum daily dose is 3.0 gm.
Storage: Adonis herb and powder should be stored carefully. | | Drug Interactions: The simultaneous administration of quinidine, calcium salts, saluretics, laxatives and glucocorticoids enhance effects and side effects.
OVERDOSAGE
For symptoms of an acute poisoning and therapy see Digitalis folium. The dangers of poisoning are relatively low with oral application, due to the poor absorbability of the glycosides.
DOSAGE
All information is based on Lilly-of-the-Valley powder as specified in the German pharmacopoeia. | | Drug Interactions: The simultaneous administration of the drug with quinidine, calcium salts, saluretics, laxatives or glucocorticoids increases both efficacy and side effects. For symptoms of an acute poisoning and therapy see Digitalis folium.
The scientific literature (Lewin) contains numerous descriptions of fatalities.
DOSAGE
No information is available.
LITERATURE
Loew D, Phytotherapie bei Herzinsuffizienz. In: ZPT 18(2):92-96. 1997.
Loew DA, Loew AD, Pharmakokinetik von herzglykosidhaltigen Pflanzenextrakten. In: ZPT 15(4): 197-202. 1994.
Siddiqui S et al. |
Tori Hudson, N.D.
See book keywords and concepts |  Most of the studies in this meta-analysis were of postmenopausal women, but some of the studies included patients who had diseases that are associated with higher risk of osteoporosis, including patients with primary biliary cirrhosis and some on glucocorticoids. These results in fracture reduction exceed those typically seen with alendronate (about 50 percent), and fewer side effects are associated with vitamin K compared to the approximately 17 percent side effect rate of reflux and esophagitis with bisphospho-nates. |
Joseph E. Mario
See book keywords and concepts |  Adrenal Glands' 3 Steroid hormones:
(1) glucocorticoids Influence Protein and Carbohydrate metabolism, necessary in stress conditions like pregnancy, severe hypertension, infectious disease, surgery, bums, and pancreatitis. glucocorticoids regulate the production of sugar from Protein to rise when blood sugar drops; control the loss of Potassium from tissues, create an Insulin resistance and enhance White blood cell effects. (2VMineralcorticoids Influence Sodium and Potassium balance. (3) Androgens Influence secondary male characteristics like testosterones, some are converted to testosterone. |
KC Craichy
See book keywords and concepts |  Corticotrophin, in turn, tells our adrenal glands to release other stress hormones, glucocorticoids, which stimulate the hippocampus—one of the parts of the brain related to memory—so we are able to deal with similar threats should they occur again. Once glucocorticoids are released into the bloodstream, the hippocampus signals the hypothalamus to stop releasing corticotrophins, ending the stress response. All of these stress responses are automatic and allow us to effectively and safely rescue ourselves.
Adrenal Fatigue
We aren't meant to experience these high stress threats often, however. |
Gabriel Cousens
See book keywords and concepts |  It can also be activated by medical problems such as pneumonia, burns, stroke, and use of certain drugs such as glucocorticoids and diuretics.
Chronic complications in both Type-1 and Type-2 diabetes are similar. They emerge from the same causal pathways. They include two main metabolic problems: the glycosylated protein and the intracellular accumulation of sorbitol. | | These tests can be thrown off by any occasion that creates an impaired glucose tolerance, including use of medications such as diuretics, glucocorticoids, nicotinic acid, and phenoytin. You are going to have more accuracy in monitoring the healing of diabetes by using two tests rather than one.
Dietary Fat and Diabetes
The role of high fat intake in diabetes has been suspected since the early twentieth century. As far back as the 1920s, Dr. S. Sweeney produced reversible diabetes in all of his medical school students by feeding them a high-vegetable-oil diet for forty-eight hours. | | Arsenic interferes with the action of glucocorticoid hormones, which belong to the same family of steroid hormones as estrogen and progesterone. glucocorticoids turn on many genes that help regulate blood sugar and even ward off cancer. Repeatedly drinking water containing certain amounts of arsenic has been linked to increased rates of cancer and diabetes. The underlying mechanism is now thought to be hormone disruption.64
LEAD
Lead exposure has been associated with an increased risk of hypertension, and is a well-established risk factor for kidney disease. |
Ann M. Coulston and Carol J. Boushey
See book keywords and concepts |  Studies on the insulin-antagonistic effect of glucocorticoids. Metabolism 28, 502-510.
161. Kelley, D. E., Mokan, M., Simoneau, J. A., and Mandarino, L. J. (1993). Interaction between glucose and free fatty acid metabolism in human skeletal muscle. /. Clin. Invest. 92, 91-98.
162. Kelley, D. E., and Mandarino, L. J. (1990). Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. J. Clin. Invest. 86, 1999-2007.
163. Kelley, D. E., and Mandarino, L. J. (2000). |
Joerg Gruenwald, Ph.D.
See book keywords and concepts | | Drug Interactions: Increase of effectiveness and thus also of side effects is possible with concomitant administration of quinidine, calcium, saluretics, laxatives and extended therapy with glucocorticoids.
The simultaneous administraton of arrhythmogenic substances (sympathomimetics, methylxanthines, phosphodiesterase inhibitors, quinidine) increases the risk of the appearance of cardiac arrhythmias. |
KC Craichy
See book keywords and concepts | | Corticotrophin, in turn, tells our adrenal glands to release other stress hormones, glucocorticoids, which stimulate the hippocampus—one of the parts of the brain related to memory—so we are able to deal with similar threats should they occur again. Once glucocorticoids are released into the bloodstream, the hippocampus signals the hypothalamus to stop releasing corticotrophins, ending the stress response. All of these stress responses are automatic and allow us to effectively and safely rescue ourselves.
Adrenal Fatigue
We aren't meant to experience these high stress threats often, however. |
Gabriel Cousens
See book keywords and concepts | | Arsenic interferes with the action of glucocorticoid hormones, which belong to the same family of steroid hormones as estrogen and progesterone. glucocorticoids turn on many genes that help regulate blood sugar and even ward off cancer. Repeatedly drinking water containing certain amounts of arsenic has been linked to increased rates of cancer and diabetes. The underlying mechanism is now thought to be hormone disruption.103
TESTOSTERONE CHANGES
Another fascinating aspect of hormonal physiology is the role of testosterone in diabetes. In the 1960s, J. |
David Winston, RH(AHG), and Steven Maimes
See book keywords and concepts |  Next, ACTH triggers the production and release of hormones called glucocorticoids (GCs), primarily Cortisol, from the adrenal cortex. The hypothalamus also stimulates the adrenal gland, via the sympathetic nervous system, to release catecholamines, such as adrenaline and noradrenaline, into the bloodstream. The combination of the release of adrenaline and noradrenaline results in the well-known fight-or-flight response. Catecholamines and GCs induce a variety of behavioral, biochemical, and physiological changes, collectively termed the stress response. | | It is the most potent of the naturally occurring glucocorticoids and is essential to metabolism as well as stress response.
Table 5.1. | | Among the cor-ticoids are the glucocorticoids, including Cortisol.
Catecholamines (adrenaline, noradrenaline) are released by the adrenal medulla and affect the sympathetic nervous system. They produce widespread effects throughout the body, including an increase in blood pressure and heart rate during times of stress.
Adrenaline (epinephrine) is normally present in the bloodstream in minute quantities. In times of excitement or stress, additional quantities are secreted, causing an effect on body structures in preparation for physical exertion (either fight or flight). |
Gabriel Cousens, M.D.
See book keywords and concepts |  Hormones that induce MT include the glucocorticoids, progesterone, and estrogen. The catacholamines that induce MT include glucagon, angiotensin, and adenosine. Growth factors that induce MT include insulin and 1GF-1. Cytokines and inflammatory agents such as carrageenan, dextran, endotoxins, interleukin-1, interleukin-6, interferon-Y, and tumor necrosis factor all will induce MT production. Vitamins that induce its production include ascorbic acid and retinoate. |
Mary-Ann Shearer
See book keywords and concepts |  The article goes on to say that sunlight (for the manufacture of vitamin D), hormones such as parathyroid hormone, growth hormone, estrogen, and progesterone enhance the absorption of calcium, while glucocorticoids, excess thyroid hormone, and possibly calcitonin suppress the absorption of calcium.
Remember that to manufacture sufficient vitamin D, unheated, unprocessed, unsaturated fats are required in the diet. |
Frederic Vagnini, M.D. and Barry Fox, Ph.D.
See book keywords and concepts |  The outer layer of the adrenal gland, called the adrenal cortex, synthesizes and releases a number of important substances, including the glucocorticoids that affect fat, protein, and carbohydrate metabolism, and helps the body produce glucose to keep the blood sugar stable between meals.
But sometimes the adrenal cortex stops producing sufficient amounts of these vital substances. Doctors call this adrenocortical insufficiency. |
Michael Friedman, ND
See book keywords and concepts |  CONVENTIONAL MEDICAL TREATMENT
POLYCYSTIC OVARY SYNDROME
Typical conventional treatment of PCOS includes oral contraceptives, progestins, androgen antagonists (spironolactone), and glucocorticoids (prednisone). Limited effectiveness and significant side effects are common. Surgery (wedge resection) is typically reserved for those who fail to respond to pharmacological treatment. Adhesions that form after surgery may prevent future pregnancy.
PREMENSTRUAL SYNDROME
A number of pharmaceutical agents are typically employed for PMS, although often with limited success. |
Bradley J. Willcox, M.D., D. Craig Willcox, Ph.D., Makoto Suzuki, M.D.
See book keywords and concepts | | For the short term, they improve memory and physical performance, but over the long term, high elevations of glucocorticoids cause decreased ability in both areas; they break down our stored carbohydrate, raise our blood sugar levels, and cause many of the age-related changes we see in overweight people.80 Consuming fewer calories helps produce the consistently right amount of glucocorticoidsjust enough to keep us sharp, but much less than we'd experience in a stressful situation. |
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