report

Clinical trial results more honest on government website than in science journals

Sunday, April 20, 2014 by: J. D. Heyes
Tags: clinical trials, government website, science journals

eTrust Pro Certified

Most Viewed Articles
Popular on Facebook
BACK INTO THE CLOSET: Why U.S. reporters are not allowed to write about rainbow events in nations where being gay is still condemned
Depopulation test run? 75% of children who received vaccines in Mexican town now dead or hospitalized
INVESTIGATION: Three days before Dr. Bradstreet was found dead in a river, U.S. govt. agents raided his research facility to seize a breakthrough cancer treatment called GcMAF
A family destroyed: Six-month-old dies after clinic injects baby with 13 vaccines at once without mother's informed consent
Biologist explains how marijuana causes tumor cells to commit suicide
BOMBSHELL: China and America already at war: Tianjin explosion carried out by Pentagon space weapon in retaliation for Yuan currency devaluation... Military helicopters now patrolling Beijing
Companies begin planting microchips under employees' skin
BAM! Chipotle goes 100% non-GMO; flatly rejecting the biotech industry and its toxic food ingredients
ECONOMIC SLAVERY FOR ALL: While we were distracted with the Confederate flag flap, Congress quietly forfeited our entire economic future via fast-track trade authority
McDonald's in global profit free fall as people everywhere increasingly reject chemically-altered toxic fast food
March Against Monsanto explodes globally... World citizens stage massive protests across 38 countries, 428 cities... mainstream media pretends it never happened
SCOTUS same-sex marriage decision may have just legalized the concealed carry of loaded firearms across all 50 states, nullifying gun laws everywhere
Vicious attack on Dr. Oz actually waged by biotech mafia; plot to destroy Oz launched after episode on glyphosate toxicity went viral
Nearly every mass shooting in the last 20 years shares one surprising thing? and it's not guns
Holistic cancer treatment pioneer Dr. Nicholas Gonzalez dies suddenly; patients mourn the loss of a compassionate, innovative doctor who helped thousands heal from cancer
Inuit Elders tell NASA Earth Axis Shifted
Wild eyes and bowl cuts: Why do mass shooters always share the same hair styles and crazed zombie stares?
Genetically white woman now claims self-identify as black: If you can choose your gender, can you also choose your race? What about your species? Can a human claim to be a llama?
Delicious
(NaturalNews) An Oregon Health & Science University (OHSU) analysis published recently in the Annals of Internal Medicine found that medical researchers very often presented the findings of their clinical trials in a different way on a federal government website then they did in the medical journals where their studies were published.

The reports of researchers in peer-reviewed medical journals, in fact, were very often more favorable to the drug or intervention being examined than the reports on the government website -- ClinicalTrials.gov -- which requires data for specific categories, says the university analysis.

'Serious adverse events' left out of journal reports

According to a press release of the findings:

One of the most notable discrepancies: Of the 84 clinical trials the researchers looked at where a "serious adverse event" was reported on ClinicalTrials.gov, 33 of those trials reported fewer adverse events in the medical journals than they had reported to the government website. In 16 of those cases, no adverse events were reported in the journals.

OHSU researchers said their analysis demonstrated the ongoing problem with inaccurate and sometimes biased reporting in medical journals. But it also showed that the government website could be another viable source for objective medical information.


"There's a general recognition that adverse events historically haven't been reported consistently in the medical literature. And underreporting of these events is a major concern because it can distort how health care providers balance the benefits and harms of drugs and other medical interventions for their patients," said Daniel Hartung, Pharm.D., M.P.H., associate professor in the Oregon State University/OHSU College of Pharmacy and lead author of the study. "But our analysis also seemed to show that ClinicalTrials.gov could be a good alternative for consumers and health care providers to get comprehensive information about a drug or medical intervention."

The researchers examined 110 medical trials which had been completed by Jan. 1, 2009, and which had also been reported on ClinicalTrials.gov. Congress required that, after September 2008, many drug clinical trials and medical interventions report their findings and results to the website, as a way to give consumers and healthcare providers better information about the results of said trials.

Discrepancies

For their study, the OHSU researchers only examined trials completed by 2009 to allow for the clinical trial results to later be published in medical journals, for comparison.

Of the 110 trials the researchers looked at, most were sponsored by industry -- paid for by the pharmaceutical industry or medical companies, for instance. The analysis found that inconsistencies between information on the same trial at ClinicalTrials.gov and in the medical journals were common.

That said, in most cases the discrepancies were small and did not necessarily affect the statistical significance of the result.

More from the University's press release:

Another discrepancy between the two areas of reporting came in how deaths that were part of the clinical trials were reported. In that circumstance, deaths seemed to be underreported or inconsistently report on ClinicalTrials.gov. For instance, in 17 percent of the trials that did not reported deaths on ClinicalTrials.gov, deaths were reported in the journal article on the trial. Prior studies have indicated ClinicalTrials.gov does not have a uniform way of reporting deaths and that may lead to inconsistencies.

"This is the most comprehensive study of ClinicalTrials.gov to date," said Mark Helfand, M.D., M.S., M.P.H., professor of medicine and medical informatics and clinical epidemiology at the OHSU School of Medicine, and a co-author of the analysis/study. "It shows that patients and clinicians could use it to find information that is not available in the published literature, particularly to get more complete information about the harms of various treatment options. It also shows that, to best serve the public, death rates and some other items in ClinicalTrials.gov should be audited to keep them up to date."

Sources:

http://www.sciencedaily.com

http://www.ohsu.edu

http://www.clinicaltrials.gov

Follow real-time breaking news headlines on
Clinical trials at FETCH.news
Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support NaturalNews.com by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite NaturalNews.com with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

GET SHOW DETAILS
+ a FREE GIFT

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.