ovarian cancer

Apigenin Phytonutrient Cuts Ovarian Cancer Risk

Tuesday, November 10, 2009 by: David Gutierrez, staff writer
Tags: ovarian cancer, health news, Natural News

eTrust Pro Certified

Delicious Pin It
(NaturalNews) High intake of foods containing the natural plant compound apigenin might decrease a woman's risk of ovarian cancer, researchers from Brigham and Women's Hospital and Harvard Medical School have found.

Apigenin is a class of flavonoid, a phytonutrient (plant compound) family known for its high antioxidant activity. Antioxidants are renowned for removing cell-damaging free radicals from the body, thereby reducing the symptoms of aging and the risk of chronic disease such as cancer and heart disease.

Foods high in apigenin include celery, parsley, tomato sauce and red wine. The compound is widely believed to be safe when consumed in plant foods, with no toxic or mutagenic effects.

In a study funded by the National Cancer Institute and the National Institutes of Health, and published in the International Journal of Cancer, researchers gave questionnaires to 1,141 ovarian cancer patients and 1,183 women of similar age to assess the content of their diets over the course of one week. The average participant age was 51. Women with ovarian cancer were more likely to be heavier and have a higher daily calorie intake, with a less healthy diet than the healthy women.

The researchers used the questionnaires to calculate the participants' intake of five different, common flavonoids: apigenin, kaempferol, luteolin, myricetin and quercetin. The bulk of these antioxidants in the women's diets came from tea, red wine, apples, blueberries, celery, kale, lettuce, oranges and tomato sauce.

Higher intake of certain rich-rich foods such as cauliflower, raisins and tomato sauce was associated with a decreased risk of ovarian cancer, though this correlation was not statistically significant. There was no correlation between total flavonoid consumption and cancer risk after adjusting for known cancer risk factors such as age, physical activity, use of oral contraceptives, and history of childbirth, breastfeeding and tubal ligation. There was also no correlation between cancer risk and any of the flavonoids except for apigenin.

Women with the highest apigenin intake, however, had a "borderline significant" 28 percent lower risk of ovarian cancer than women with the lowest intake, after adjusting for other risk factors and intake of the other four flavonoids.

Ovarian cancer is among the most lethal forms of cancer in women. There are 20,000 new cases in the United States each year, leading to 15,000 deaths per year. According to the Ovarian Cancer National Alliance, the disease affects one in 69 women and kills one in 95.

This study is not the first to indicate a connection between apigenin and decreased cancer risk. Previous research has found that apigenin decreases the structural stability and inhibits the expression of a protein that is involved in the migration of ovarian cancer cells to other parts of the body. It has also been more directly observed to interfere with the movement of ovarian cancer cells. Apigenin has also been shown to inhibit the expression in ovarian cancer cells of a protein linked to the development of blood vessels in tumors, as well as overall tumor growth.

Other studies have found that apigenin inhibits the growth of some breast cancers and may induce programmed cell death. Higher intake of other flavonoids has also been shown to reduce the risk of ovarian cancer.

The researchers in the current study speculated that flavonoids may also help reduce ovarian cancer risk simply by functioning as antioxidants, eliminating free radicals that have been linked to DNA damage. More specifically, apigenin and other flavonoids might inhibit the effect of estrogen in the body either by reducing circulating levels or by blocking estrogen receptors.

"These mechanisms could be important in inhibiting ovarian carcinogenesis, due to the estrogen-rich environment within the ovaries and the proliferative effect of estrogen on ovarian epithelial cells," the researchers wrote.

Sources for this story include: www.reuters.com; www.nutraingredients.com.

Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Join over four million monthly readers. Email privacy 100% protected. Unsubscribe at any time.


Have comments on this article? Post them here:

comments powered by Disqus

Take Action: Support NaturalNews.com

Email this article to a friend

Permalink to this article:

Reprinting this article: Non-commercial use OK, cite NaturalNews.com with clickable link.

Embed article link: (copy HTML code below):
Most Popular
Today | Week | Month | Year

See all Top Headlines...



GET SHOW DETAILS
+ a FREE GIFT

Now Available at ShopNaturalNews.com

O3 Essentials OraJuvenate™
A powerful, cleansing dental cream for maximum oral/dental health.
New Cancer Solutions
Over 3 hours of content covering today’s best cancer tests, how to kill cancer cells and the best diets and exercise routines.
Freeze-Dried 100% Organic Whole Corn
Our freeze-drying method preserves taste, texture and nutrients better than any other food preservation method ever invented.
Fenix TK35 Flashlight
Tough, waterproof, extremely bright and it’s touted to throw an 800+ lumen beam more than 1,000 feet into the night.
Inca Treasure Smoothie Pack
This pack of our four most popular superfoods from South America is the perfect combo pack for smoothie lovers.
Pink Himalayan Salt
This salt delivers significant levels of magnesium, zinc and selenium, with trace levels of dozens of other elements.
Pinhole Glasses - Aviator Style
Pinhole glasses are becoming famous for helping people improve their vision without the risks of laser surgery.
Oxy-Rich Facial Serum
O3 Essentials Jojoba Oxy-Rich Facial Serum is cellular nourishment for your skin. Helps smooth fine lines while enhancing tissue elasticity.
Freeze-Dried 100% Blackberry Halves
Our freeze-dried blackberry halves are grown in Serbia under strict organic standards.

Also on NaturalNews:

Health Ranger Videos
Activist music
CounterThink Cartoons
Food documentaries
FREE Special Reports
Podcasts
Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

Most Popular Stories

Flu shot kills 19-year-old, but vaccine industry still has total immunity against lawsuits
Here's a nutty fact: Eating more tree nuts lowers the risk of all-cause death by up to 20 percent
Six important facts you're not being told about lost Malaysia Airlines Flight 370
Malaysia Airlines Flight 370 now clearly a government cover-up: All evidence contradicts official story
10 other companies that use the same Subway yoga mat chemical in their buns
BLM fracking racket exposed! Armed siege and cattle theft from Bundy ranch really about fracking leases
High-dose vitamin C injections shown to annihilate cancer
U.S. treating meat with ammonia, bleach and antibiotics to kill the '24-hour sickness'
USDA to allow U.S. to be overrun with contaminated chicken from China
Vaccine fraud exposed: Measles and mumps making a huge comeback because vaccines are designed to fail, say Merck virologists
Battle for humanity nearly lost: global food supply deliberately engineered to end life, not nourish it
Diet soda, aspartame linked to premature deaths in women

25 Amazing Facts About Food

This FREE downloadable report unveils a collection of astonishing and little-known facts about the food we eat very day. Click here to read it now...

 

Resveratrol and its Effects on Human Health and Longevity - Myth or Miracle.

Unlock the secrets of cellular health with the "miracle" nutrient Resveratrol Click here to read it now...

 

Nutrition Can Save America

FREE online report shows how we can save America through a nutrition health care revolution. "Eating healthy is patriotic!" Click here to read it now...

The Healing Power of Sunlight and Vitamin D

In this exclusive interview, Dr. Michael Holick reveals fascinating facts on how vitamin D is created and used in the human body to ward off chronic diseases like cancer, osteoporosis, mental disorders and more. Click here to read it now...

Vaccines: Get the Full Story

The International Medical Council on Vaccination has released, exclusively through NaturalNews.com, a groundbreaking document containing the signatures of physicians, brain surgeons and professors, all of which have signed on to a document stating that vaccines pose a significant risk of harm to the health of children. Click here to read it now...

Health Ranger Storable Organics

GMO-free, chemical-free foods and superfoods for long-term storage and preparedness. See selection at www.StorableOrganics.com



Recommended Resources On:

Natural News trends
Health Ranger news
Natural News GMOs
Mike Adams tracker
Natural News photos
Natural News Global
Natural News in focus
Natural News connect
Natural News shocking stories
Natural News radar
GMOs
Quackwatch
Vaccines
Health freedom
Dr. Paul Offit

This site is part of the Natural News Network © 2014 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

eTrust Pro Certified Android app on Google Play

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.