Preliminary Clinical Trial Shows Grapeseed Extract in Moxxor Reduces Exercise-Induced Oxidative Stress

Tuesday, January 06, 2009
by Mike Adams, the Health Ranger
Editor of (See all articles...)
Tags: grapeseed extract, Moxxor, health news

eTrust Pro Certified

Most Viewed Articles
Popular on Facebook
CDC issues flu vaccine apology: this year's vaccine doesn't work!
The five biggest lies about Ebola being pushed by government and mass media
Ultraviolet light robot kills Ebola in two minutes; why doesn't every hospital have one of these?
Tetanus vaccines found spiked with sterilization chemical to carry out race-based genocide against Africans
Biologist explains how marijuana causes tumor cells to commit suicide
Companies begin planting microchips under employees' skin
The best way to help your body protect itself against Ebola (or any virus or bacteria)
NJ cops bust teenagers shoveling snow without a permit
Russia throws down the gauntlet: energy supply to Europe cut off; petrodollar abandoned as currency war escalates
McDonald's in global profit free fall as people everywhere increasingly reject chemically-altered toxic fast food
W.H.O. contradicts CDC, admits Ebola can spread via coughing, sneezing and by touching contaminated surfaces
Top ten things you need to do NOW to protect yourself from an uncontrolled Ebola outbreak
Chemotherapy kills cancer patients faster than no treatment at all
FDA targets Dr. Bronner's Magic Soaps for sharing health benefits of coconut oil
U2's Bono partners with Monsanto to destroy African agriculture with GMOs
Why flu shots are the greatest medical fraud in history
Governments seize colloidal silver being used to treat Ebola patients, says advocate
Flu vaccine kills 13 in Italy; death toll rises

(NaturalNews) A preliminary clinical trial has been completed by Dr. Glenn Vile in conjunction with HortResearch, a New Zealand research institution. Although the number of participants in the trial is small (eleven competitive rowers), the double-blind nature of the trial and the preliminary results indicate that the grapeseed extract used in Moxxor (a marine omega-3 nutritional supplement) may be beneficial as a dietary supplement for helping reduce oxidative stress during exercise.

Here's how the trial was structured: One hour prior to exercise, competitive rowers were given either 150mg of grapeseed extract (GSE) or 150mg of placebo (glucose). A second dose of the same amount was given after the 30-minute exercise session. Blood samples were taken one hour prior to exercise and one hour after exercise.

The blood samples were analyzed to determine the level of lactate dehydrogenase (LDH), a chemical marker of oxidative stress and muscle damage. The results of this preliminary trial reveal that those rowers who took the grapeseed extract used in Moxxor experienced a 34% reduction in LDH levels (plus or minus 6%).

The author's conclusion of this study is included below, along with full references.

While the study was too small to support sweeping generalizations about GSE and exercise for the population as a whole, it does provide justified optimism for further study of grapeseed extract as potential reducer of exercise-induced oxidative stress. This may mean (although there is no proof of this yet) that GSE might also be a useful element to study in the prevention of heart disease or cancer. Recent laboratory research conducted at the University of Kentucky, in fact, reveals that GSE causes leukemia cells to commit suicide (apoptosis), thereby positioning grapeseed extract as a potentially useful anti-cancer element for further study.

If you are interested in taking Moxxor, by the way, there are currently over 1,000 NaturalNews readers who are Moxxor members, and they can introduce you to the remarkable health properties of this marine omega-3 oil that contains grapeseed extract from New Zealand. Simply go to and click on the city nearest you to find a NaturalNews Moxxor team member. Then contact them by phone or email to learn more.

You can also read more about the science behind Moxxor's anti-inflammatory properties here:

Note: This article makes no health claims about Moxxor, and Moxxor is not intended to diagnose, treat or prevent any disease. I have a financial stake in the success of Moxxor, and I currently take six to eight capsules of Moxxor each day. It should also be noted that Dr. Glenn Vile has a financial stake in the success of grapeseed extract, as he is one of the founders of New Zealand Extracts, which you can read about here:

The company's grapeseed products are described here (very interesting reading):

It's also worth noting that the grapeseed extract used in this study is the exact same grapeseed extract used in Moxxor.

MOXXOR Antioxidant and Exercise

Here's the text of the preliminary study from Dr. Glenn Vile:

The increased demand for energy during exercise requires an increased oxygen supply to active tissues and an increased metabolic rate. Based on our current understanding that there is a balance between oxidative stress and our antioxidant defense mechanisms it would be predicted that the increased oxygen supply and metabolic rate associated with exercise would overwhelm our antioxidant defense mechanisms and lead to increased levels of oxidative stress. There is good evidence that is the case. Oxidative damage to lipids, proteins, and DNA occurs in both trained and untrained volunteers during, and for up to 24hrs after, taking part in activities such as alpine ski racing, long distance running, and cycling (Shing et al 2007, Subudhi et al 2001, Mastaloudis et al 2001, Ramel et al 2004, Aguilo et al 2005, Goldfarb et al 2005 and Itoh H et al 2000).

Antioxidants, particularly vitamin E, are depleted during exercise (Mastaloudis et al 2001 and Aguilo et al 2005), and recent evidence suggests that the dietary intake of antioxidants by athletes is lower than the general population (Machefer et al 2007). Supplementation with antioxidants prior to exercising reduces the oxidative damage that occurs during exercise. Antioxidants that have been shown to be effective include vitamins E and/or C (Aguilo et al 2005, Goldfarb et al 2005, Itoh et al 2000, Bryant et al 2004 and Bloomer et al 2004), and polyphenolic compounds of the type that are found in Grape Seed Extract (Morillis et al 2005, Pilaczynska-Szczesniak et al 2005 and Murase et al 2005). In addition antioxidant supplementation enhances aerobic performance in athletes (Aguilo et al 2007).

A daily dose of 35-110 mg of polyphenolic compounds, such as those found in MOXXOR Grape Seed Extract, has been shown to be effective in reducing oxidative damage and preventing the depletion of vitamin E that occurs during normal and strenuous levels of activity (Pilaczynska-Szczesniak et al 2005, Murase et al 2005 and Simonetti et al 2002).

Antioxidant supplementation prior to exercise has been shown to decrease some of the unwanted consequences of exercise e.g. muscle soreness (Bloomer et al 2004) but at this stage there is no evidence that antioxidant supplementation improves exercise performance (Itoh et al 2000 and Bloomer et al 2004).

The high antioxidant activity of MOXXOR grape seed extract has been demonstrated in test tube assays (Oxygen Radical Absorbance Capacity or ORAC assays) and in cytoprotection assays with cultured human cells.

In order to determine if MOXXOR grape seed extract is able to protect athletes from muscle damage that occurs as a consequence of the increased levels of oxidative stress generated during exercise, MOXXOR in conjunction with HortResearch, a New Zealand research institution, have performed a preliminary clinical trial.

Eleven well trained rowers completed a full cross-over trial. One hour prior to a 30 min maximal rowing ergo-meter test the participants were given a capsule containing either 150mg of MOXXOR grape seed extract or 150mg of glucose (a placebo, and a double blind cross-over trial). A second capsule of 150 mg was given immediately post-exercise bringing the total dose to 300mg. Blood samples were taken one hour prior to exercise and one hour after exercise and lactate dehydrogenase (LDH) was measured in plasma samples as an indicator of muscle damage.

As expected, levels of LDH significantly increased in the blood one hour following the rowing ergo-meter exercise. An acute total dose of 300mg of MOXXOR grape seed extract decreased the release of LDH by 34 +/-6%. The results of this preliminary trial indicate that MOXXOR grape seed extract may be effective at reducing the muscle damage that occurs in trained athletes following exercise.


Aguilo A, Tauler P, Fuentespina E, Tur JA, Cordova A, and Pons A (2005). Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol Behav 31:1-7.

Aguilo A, Tauler P, Sureda A, Cases N, Pons A (2007). Antioxidant diet supplementation enhances aerobic performance in amateur sports men. J. Sports Sci. 25:1203-1210.

Bloomer RJ, Goldfarb AH, McKenzie MJ, You T and Nguyen L (2004). Effects of antioxidant therapy in women exposed to eccentric exercise. Int J Sport Nutr Exerc Metab 14:377-388.

Bryant RJ, Ryder J, Martino P, Kim J and Craig BW (2003). Effects of vitamin C and E supplementation either alone or in combination on exercise-induced lipid peroxidation in trained cyclists. J Strength Con Res 17:792-800.

Goldfarb AH, Bloomer RJ and McKenzie MJ (2005). Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise. Med Sci Sports Exerc 37: 234-239.

Itoh H, Ohkuwa T, Yamazaki, Shimoda T, Wakayma A, Tamura S, Yamamoto T, Sato Y and Miyamura M (2000). Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. Int J Sports Med 21:369-374.

Machefer G, Groussard C, Zouhal H, Vincent S, Youssef H, Faure H, Malarde L, Gratas-Delamarche A (2007). Nutritional and plasmatic antioxidant vitamins status of ultra endurance athletes. J Am Coll Nutr 26:311-316.

Mastaloudis A, Leonard SW and Traber MG (2001). Oxidative stress during extreme endurance exercise. Free Radic Biol Med 31:911-922.

Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.

About the author:Mike Adams (aka the "Health Ranger") is the founding editor of, the internet's No. 1 natural health news website, now reaching 7 million unique readers a month.

In late 2013, Adams launched the Natural News Forensic Food Lab, where he conducts atomic spectroscopy research into food contaminants using high-end ICP-MS instrumentation. With this research, Adams has made numerous food safety breakthroughs such as revealing rice protein products imported from Asia to be contaminated with toxic heavy metals like lead, cadmium and tungsten. Adams was the first food science researcher to document high levels of tungsten in superfoods. He also discovered over 11 ppm lead in imported mangosteen powder, and led an industry-wide voluntary agreement to limit heavy metals in rice protein products to low levels by July 1, 2015.

In addition to his lab work, Adams is also the (non-paid) executive director of the non-profit Consumer Wellness Center (CWC), an organization that redirects 100% of its donations receipts to grant programs that teach children and women how to grow their own food or vastly improve their nutrition. Click here to see some of the CWC success stories.

With a background in science and software technology, Adams is the original founder of the email newsletter technology company known as Arial Software. Using his technical experience combined with his love for natural health, Adams developed and deployed the content management system currently driving He also engineered the high-level statistical algorithms that power, a massive research resource now featuring over 10 million scientific studies.

Adams is well known for his incredibly popular consumer activism video blowing the lid on fake blueberries used throughout the food supply. He has also exposed "strange fibers" found in Chicken McNuggets, fake academic credentials of so-called health "gurus," dangerous "detox" products imported as battery acid and sold for oral consumption, fake acai berry scams, the California raw milk raids, the vaccine research fraud revealed by industry whistleblowers and many other topics.

Adams has also helped defend the rights of home gardeners and protect the medical freedom rights of parents. Adams is widely recognized to have made a remarkable global impact on issues like GMOs, vaccines, nutrition therapies, human consciousness.

In addition to his activism, Adams is an accomplished musician who has released ten popular songs covering a variety of activism topics.

Click here to read a more detailed bio on Mike Adams, the Health Ranger, at

comments powered by Disqus
Take Action: Support by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...


Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of, the internet's No. 1 natural health news site. (Source:

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.