Alzheimer

Despite the Hype, Statin Drugs Found Medically Useless in Preventing Alzheimer's

Monday, September 08, 2008
by Mike Adams, the Health Ranger
Editor of NaturalNews.com (See all articles...)
Tags: statin drugs, health news, Natural News

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(NaturalNews) Cholesterol-lowering statin drugs do not provide any protection against Alzheimer's disease, according to a study conducted by researchers from the Rush University Medical Center in Chicago and published in Neurology, the journal of the American Academy of Neurology.

"This study adds to the growing evidence that statins don't lower the risk of Alzheimer's disease," lead researcher Zoe Arvanitakis said. "The study also found no association between taking statins and a slower cognitive decline among older people."

Prior studies on animals have suggested that taking statins might lower the risk of developing Alzheimer's disease, and a human study in 2000 found that the disease was less common in those who took the cholesterol drugs. Researchers have speculated that this result might arise from the fact that cholesterol and inflammation are known to play a role in the development of Alzheimer's, and statins tend to reduce levels of both.

But a number of studies since 2000 have failed to replicate the same effect, leading many doctors to conclude that the drugs do not actually provide a benefit for cognitive health.

"There is good evidence that statins do not prevent Alzheimer's," said Dr. James Wright of the University of British Columbia, remarking on the body of current evidence.

The current study was conducted on 929 Catholic clergy members taking part in the Religious Orders Study on aging and Alzheimer's disease. All participants had no signs of dementia when the study began in January 1994. Just over 68 percent of them were female, and the average starting age was 75. The study was funded by grants from the National Institute on Aging.

The rate of statin use among the 191 participants who developed Alzheimer's disease was approximately the same as the rate of use in the general participant pool, leading the researchers to conclude that statins had no effect on the development of the disease. A brain autopsy was also conducted on all 250 participants who died during the study, and the researchers found no effect of statins on the occurrence of brain markers of Alzheimer's disease or strokes.

Strokes and Alzheimer's disease are the two primary causes of dementia, which is defined as a decrease in cognitive function greater than would normally be expected from aging.

Statin use also failed to protect against the cognitive decline associated with Alzheimer's disease, such as memory loss. Researchers measured cognitive function through a series of 19 tests of five different measures once per year for 12 years, until the study's conclusion in November 2006. Each participant's global cognition score was derived by combining the scores for measurements of episodic memory, semantic memory, working memory, perceptual speed and visuospatial ability.

There was no association between statin use and the level of global cognition, nor was it associated with the rate of change in global cognition over time. Among only patients who developed Alzheimer's disease, statin use likewise failed to show any effect on the rate of cognitive decline.

According to Larry Sparks, director of the Roberts Laboratory for Neurodegenerative Disease Research at the Sun Health Research Institute in Arizona, the sample size of the Rush study was too small to conclusively rule out statins as beneficial for Alzheimer's prevention. Sparks, one of the first researchers to report such a connection, says that the type of statin used might make a difference in the effect.

"Research suggests that statins that don't get into the brain may prevent or slow the progression of Alzheimer's," he said.

The Rush researchers did in fact test for any difference between two kinds of statins, depending on whether they were more or less lipophilic. Neither kind had any effect.

Sparks said he has had success in treating mild or moderate cases of Alzheimer's with statins. But Arvanitakis disagreed with this assessment.

"Physicians should not prescribe them for Alzheimer's disease," Arvanitakis said.

William Thies of the Alzheimer's Association said it is too early to totally rule out statins as beneficial for Alzheimer's. He expects a final answer from clinical trials that are currently ongoing. But he noted that as long as the issue remains unsettled, "there is no recommendation that you take statins for Alzheimer's disease."

Some researchers have speculated that early studies may have shown a cognitive benefit from statins simply due to the fact that people who are more concerned about their health appear to have a reduced risk of developing Alzheimer's disease. People who are more concerned about their health are also more likely to take statins, which may create a correlation between statin use and decreased Alzheimer's risk where no causation exists.

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About the author:Mike Adams (aka the "Health Ranger") is the founding editor of NaturalNews.com, the internet's No. 1 natural health news website, now reaching 7 million unique readers a month.

In late 2013, Adams launched the Natural News Forensic Food Lab, where he conducts atomic spectroscopy research into food contaminants using high-end ICP-MS instrumentation. With this research, Adams has made numerous food safety breakthroughs such as revealing rice protein products imported from Asia to be contaminated with toxic heavy metals like lead, cadmium and tungsten. Adams was the first food science researcher to document high levels of tungsten in superfoods. He also discovered over 11 ppm lead in imported mangosteen powder, and led an industry-wide voluntary agreement to limit heavy metals in rice protein products to low levels by July 1, 2015.

In addition to his lab work, Adams is also the (non-paid) executive director of the non-profit Consumer Wellness Center (CWC), an organization that redirects 100% of its donations receipts to grant programs that teach children and women how to grow their own food or vastly improve their nutrition. Click here to see some of the CWC success stories.

With a background in science and software technology, Adams is the original founder of the email newsletter technology company known as Arial Software. Using his technical experience combined with his love for natural health, Adams developed and deployed the content management system currently driving NaturalNews.com. He also engineered the high-level statistical algorithms that power SCIENCE.naturalnews.com, a massive research resource now featuring over 10 million scientific studies.

Adams is well known for his incredibly popular consumer activism video blowing the lid on fake blueberries used throughout the food supply. He has also exposed "strange fibers" found in Chicken McNuggets, fake academic credentials of so-called health "gurus," dangerous "detox" products imported as battery acid and sold for oral consumption, fake acai berry scams, the California raw milk raids, the vaccine research fraud revealed by industry whistleblowers and many other topics.

Adams has also helped defend the rights of home gardeners and protect the medical freedom rights of parents. Adams is widely recognized to have made a remarkable global impact on issues like GMOs, vaccines, nutrition therapies, human consciousness.

In addition to his activism, Adams is an accomplished musician who has released ten popular songs covering a variety of activism topics.

Click here to read a more detailed bio on Mike Adams, the Health Ranger, at HealthRanger.com.

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