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Scientists have long believed that only aerobic exercise that builds up long-term endurance, such as running, has any notable effect on the body's metabolism. This kind of exercise produces what is known as "type I" muscle, which is designed for a long, slow output of energy. In contrast, "type II" muscle, which is used for sprinting or lifting heavy weights, is more powerful, but only in the short term. Researchers genetically engineered mice so that their bodies would produce more type II muscle when a specific gene was switched on. With the gene switched off, the mice were fed a high-calorie, sugary diet for eight weeks. As expected, the mice became obese, developed fatty liver deposits and became insulin resistant, just like humans on a similar diet. When the researchers switched the gene on and the mice began to bulk up with type II muscle, the animals quickly lost weight and were cured of their insulin resistance and fatty liver disease. Significantly, the mice did not increase their level of exercise and continued with the high-calorie diet. "We've shown that type II muscle does more than allow you to pick up heavy objects," said researcher Kenneth Walsh. "It is also important in controlling whole-body metabolism." While the animals did not remain fat as researchers expected, they also did not become skinny like marathon runners; instead, they became lean like sprinters. Significantly, the mice's long-term endurance on a treadmill test was not improved after the gene was switched on. "These data ... suggest that strength training, in addition to the widely prescribed therapy of endurance training, may be of particular benefit to overweight individuals," the researchers wrote. Related CounterThink Cartoons:
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