BPA

Suspicion lingers over bisphenol A and breast cancer (press release)

Friday, October 13, 2006 by: NaturalNews
Tags: health news, Natural News, nutrition

eTrust Pro Certified

Delicious Pin It
Bisphenol A, a common industrial chemical claimed to speed the growth of human breast and ovarian cancers, retains its carcinogenic properties even after being modified by body processes, report Indiana University and University of California at Berkeley scientists in the Aug. 28th issue of Chemistry & Biology, a Cell Press journal.

Defenders of bisphenol A's use have argued that its natural modification inside the human body renders the estrogen-like chemical harmless.

"We tested whether this chemical modification -- the addition of sulfate to BPA -- keeps the chemical from being absorbed by breast tumor cells," said IU Bloomington biochemist Theodore Widlanski, who led the project. "We've shown that modified versions of bisphenol A likely to be formed in the body do stimulate breast tumor cell growth in vitro. Enzymes present on the surface of breast tumor cells appear to convert the modified BPA back into BPA."

BPA is a plasticizer present at low levels in mineral water bottles, CDs and DVDs, car parts and other household products. A recent U.S. Center for Disease Control and Prevention study found trace amounts of BPA in 95 percent of urine samples collected from American adults.

The researchers present a model for the selective uptake of BPA into breast cancer cells by implicating human enzymes that sulfate and de-sulfate BPA.

One of those enzymes, estrogen sulfotransferase, adds sulfate to estrogen, making the molecule water soluble and easily transportable through the bloodstream. Widlanski's collaborators showed that BPA, too, can be sulfated by estrogen sulfotransferase.

Breast cancer cells are known to overproduce an enzyme that other, healthier cells don't -- aryl sulfatase C. Aryl sulfatase C removes sulfate from estrogen, allowing the hormone's absorption into cells. In the present Chemistry & Biology paper, Widlanski's group shows aryl sulfatase C can also de-sulfate BPA, and that the concentration of non-sulfated BPA inside breast cancer cells goes up when the cells are grown in a medium containing sulfated BPA.

That human enzymes are capable of the sulfation and desulfation of BPA suggests breast cancer cells are a lightning rod not only for natural estrogen, but for BPA too, Widlanski said.

Widlanski cautions those who would misinterpret the results of the study.

"We have not shown this process takes place in vivo," he said. "We have only demonstrated a possible mechanism that explains what people have been speculating about for years. It doesn't mean that your bottled water is any less safe today than it was yesterday. It just means that if it isn't safe, we might be able to explain why."

Widlanski said that he has always been a skeptic of claims that BPA causes or speeds the development of cancer and birth defects. "All along we set out to show the opposite -- that BPA is not harmful. If any of the answers to our questions had been 'no,' then we would have concluded BPA was not dangerous. But we can't do that, or we can't do it yet."

The researchers subjected cancer cells and enzymes to extremely high concentrations of BPA and BPA derivatives -- levels not ordinarily experienced by human beings. Widlanski said his group did this in order to simulate the cumulative effects of low BPA concentrations of the course of a human lifetime.

"If our hypothesis is true about BPA, it's probably going to be the sum of effects of a lot of cancer-causing compounds that is responsible for the disease," Widlanski said. "We would not anticipate that BPA or any other single chemical is the only culprit here."

Contact: David Bricker brickerd@indiana.edu 812-219-8308 Indiana University

Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Join over four million monthly readers. Email privacy 100% protected. Unsubscribe at any time.


Have comments on this article? Post them here:

comments powered by Disqus

Take Action: Support NaturalNews.com

Email this article to a friend

Permalink to this article:

Reprinting this article: Non-commercial use OK, cite NaturalNews.com with clickable link.

Embed article link: (copy HTML code below):
Most Popular
Today | Week | Month | Year

See all Top Headlines...



GET SHOW DETAILS
+ a FREE GIFT

Now Available at ShopNaturalNews.com

O3 Essentials OraJuvenate™
A powerful, cleansing dental cream for maximum oral/dental health.
New Cancer Solutions
Over 3 hours of content covering today’s best cancer tests, how to kill cancer cells and the best diets and exercise routines.
Freeze-Dried 100% Organic Whole Corn
Our freeze-drying method preserves taste, texture and nutrients better than any other food preservation method ever invented.
Fenix TK35 Flashlight
Tough, waterproof, extremely bright and it’s touted to throw an 800+ lumen beam more than 1,000 feet into the night.
Inca Treasure Smoothie Pack
This pack of our four most popular superfoods from South America is the perfect combo pack for smoothie lovers.
Pink Himalayan Salt
This salt delivers significant levels of magnesium, zinc and selenium, with trace levels of dozens of other elements.
Pinhole Glasses - Aviator Style
Pinhole glasses are becoming famous for helping people improve their vision without the risks of laser surgery.
Oxy-Rich Facial Serum
O3 Essentials Jojoba Oxy-Rich Facial Serum is cellular nourishment for your skin. Helps smooth fine lines while enhancing tissue elasticity.
Freeze-Dried 100% Blackberry Halves
Our freeze-dried blackberry halves are grown in Serbia under strict organic standards.

Also on NaturalNews:

Health Ranger Videos
Activist music
CounterThink Cartoons
Food documentaries
FREE Special Reports
Podcasts
Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

Most Popular Stories

Flu shot kills 19-year-old, but vaccine industry still has total immunity against lawsuits
Here's a nutty fact: Eating more tree nuts lowers the risk of all-cause death by up to 20 percent
Six important facts you're not being told about lost Malaysia Airlines Flight 370
Malaysia Airlines Flight 370 now clearly a government cover-up: All evidence contradicts official story
10 other companies that use the same Subway yoga mat chemical in their buns
BLM fracking racket exposed! Armed siege and cattle theft from Bundy ranch really about fracking leases
High-dose vitamin C injections shown to annihilate cancer
U.S. treating meat with ammonia, bleach and antibiotics to kill the '24-hour sickness'
USDA to allow U.S. to be overrun with contaminated chicken from China
Vaccine fraud exposed: Measles and mumps making a huge comeback because vaccines are designed to fail, say Merck virologists
Battle for humanity nearly lost: global food supply deliberately engineered to end life, not nourish it
Diet soda, aspartame linked to premature deaths in women

25 Amazing Facts About Food

This FREE downloadable report unveils a collection of astonishing and little-known facts about the food we eat very day. Click here to read it now...

 

Resveratrol and its Effects on Human Health and Longevity - Myth or Miracle.

Unlock the secrets of cellular health with the "miracle" nutrient Resveratrol Click here to read it now...

 

Nutrition Can Save America

FREE online report shows how we can save America through a nutrition health care revolution. "Eating healthy is patriotic!" Click here to read it now...

The Healing Power of Sunlight and Vitamin D

In this exclusive interview, Dr. Michael Holick reveals fascinating facts on how vitamin D is created and used in the human body to ward off chronic diseases like cancer, osteoporosis, mental disorders and more. Click here to read it now...

Vaccines: Get the Full Story

The International Medical Council on Vaccination has released, exclusively through NaturalNews.com, a groundbreaking document containing the signatures of physicians, brain surgeons and professors, all of which have signed on to a document stating that vaccines pose a significant risk of harm to the health of children. Click here to read it now...

Health Ranger Storable Organics

GMO-free, chemical-free foods and superfoods for long-term storage and preparedness. See selection at www.StorableOrganics.com



Recommended Resources On:

Natural News trends
Health Ranger news
Natural News GMOs
Mike Adams tracker
Natural News photos
Natural News Global
Natural News in focus
Natural News connect
Natural News shocking stories
Natural News radar
GMOs
Quackwatch
Vaccines
Health freedom
Dr. Paul Offit

This site is part of the Natural News Network © 2014 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

eTrust Pro Certified Android app on Google Play

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.