Researchers reveal how long-term use of anti-inflammatory medication can cause osteoporosis (press release)

Email this article to a friend

Printable Version

Articles Related to This Article: • How to Beat and Prevent Osteoporosis Naturally • Depression, Osteoporosis Correlation Misreported by Junk Science Media, Ill-Informed Health Researchers • Osteoporosis remains undiagnosed in millions of Americans; here's how to beat the disease with nutrition, exercise and sunlight Support NaturalNews advertisers - Advertise with NaturalNews Help support NaturalNews with health books and educational programs from Truth Publishing: • Swine Flu Advanced Preparedness • 8 Weeks to Vibrant Health • Raw In Ten Minutes (recipes) • How to Halt Diabetes in 25 Days ... and much more.

The steroid hormones glucocorticoids (GCs) are used at high doses to treat inflammatory and immune disorders, however they prompt bone loss and can cause osteoporosis, particularly when administered for prolonged periods. In a study appearing online on July 27 in advance of print publication in the August issue of the Journal of Clinical Investigation, Steven Teitelbaum and colleagues from Washington University School of Medicine investigated how GCs alter the activity of the bone-forming and bone-degrading cells known as osteoblasts and osteoclasts, respectively.

The authors compared the effects of the GC dexamethasone (commonly used to treat rheumatoid arthritis) on bone-degrading osteoclasts and their precursors cells from healthy mice, with its effects on the same cells derived from mice with disruption of the GC receptor. In healthy mice they found that while the steroid prolonged the longevity of osteoclasts, their bone-degrading capacity was suppressed. In mice lacking the GC receptor, no such effects were observed. It was previously known that bone degradation by osteoclasts stimulated new bone formation by osteoblasts. The results of the current study indicate that it is the GC-induced delay in the death of osteoclasts that dampens osteoblast activity and as such retards new bone formation, resulting in GC-induced osteoporosis.

Contact: Brooke Grindlinger press_releases@the-jci.org 212-342-9006 Journal of Clinical Investigation

Get articles like this delivered to you FREE in our popular email newsletter

Related CounterThink Cartoons:

Related Articles: • How to Beat and Prevent Osteoporosis Naturally • Depression, Osteoporosis Correlation Misreported by Junk Science Media, Ill-Informed Health Researchers • Osteoporosis remains undiagnosed in millions of Americans; here's how to beat the disease with nutrition, exercise and sunlight	Take Action: Support NaturalNews.com Email this article to a friend Share this article on: NewsVine | digg | del.icio.us Permalink to this article: http://www.NaturalNews.com/020569_osteoporosis_medication_natural_health.html Reprinting this article: Non-commercial use OK, cite NaturalNews.com with clickable link. Embed article link: (copy HTML code below): <a href = "http://www.NaturalNews.com/020569_osteoporosis_medication_natural_health.html">Researchers reveal how long-term use of anti-inflammatory medication can cause osteoporosis (press release)</a>