What makes us different? Read our Declaration of Journalistic Independence Home | About Natural News | Contact Us | Write for Natural News

Pepper Component Hot Enough to Trigger Suicide in Prostate Cancer Cells (press release)

Monday, August 14, 2006 by: NaturalNews | Key concepts: cancer, PSA and prostate cancer

Want stories like this e-mailed to you? Click here for free email alerts

Email this article to a friend Printable Version

Personal Health Solutions from NaturalNews

Replace your toxic laundry detergent with natural laundry soap that grows on trees! (Popular solution!)
This top "underground" natural health newsletter brings you amazing new natural cures each month. Save $100!
How to treat and cure over 100 health conditions using little-known health secrets
How to halt type-2 diabetes with nutritional therapy - over 50% cure rate proven in studies
End cravings with this guide to natural appetite suppressants (Download edition available.)
How to blend nutritious meals in minutes with Adams' Superfood smoothie recipes (Delicious!)
Breakthrough LED lighting technology prevents global warming, saves 90% on your lighting bill

Browse more health books...
Shop our eco-friendly products...

All sales help fund NaturalNews operations.
Capsaicin, the stuff that turns up the heat in jalapeños, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, according to studies published in the March 15 issue of Cancer Research.

According to a team of researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, in collaboration with colleagues from UCLA, the pepper component caused human prostate cancer cells to undergo programmed cell death or apoptosis.

Capsaicin induced approximately 80 percent of prostate cancer cells growing in mice to follow the molecular pathways leading to apoptosis. Prostate cancer tumors treated with capsaicin were about one-fifth the size of tumors in non-treated mice.

“Capsaicin had a profound anti-proliferative effect on human prostate cancer cells in culture,” said Sören Lehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Center and the UCLA School of Medicine. “It also dramatically slowed the development of prostate tumors formed by those human cell lines grown in mouse models.”

Lehmann estimated that the dose of pepper extract fed orally to the mice was equivalent to giving 400 milligrams of capsaicin three times a week to a 200 pound man, roughly equivalent to between three and eight fresh habañera peppers – depending on the pepper’s capsaicin content. Habañeras are the highest rated pepper for capsaicin content according to the Scoville heat index. Habañera peppers, which are native to the Yucatan, typically contain up to 300,000 Scoville units.

The more popular Jalapeño variety from Oaxaca, Mexico, and the southwest United States, contains 2,500 to 5,000 Scoville units. As described in their study, the scientists observed that capsaicin inhibited the activity of NF-kappa Beta, a molecular mechanism that participates in the pathways leading to apoptosis in many cell types.

Apoptosis is a normal cellular event in many tissues that maintains a balance between newer replacement cells and aged or worn cells. In contrast, cancer cells seek to be immortal and often dodge apoptosis by mutating or deregulating the genes that participate in programmed cell death.

“When we noticed that capsaicin affected NF-kappa Beta, that was an indication that we might expect some of the apoptotic proteins to be affected,” said the study’s senior author, Phillip Koeffler, M.D., director of Hematology and Oncology, Cedars-Sinai Medical Center, and professor at UCLA.

The pepper extract also curbed the growth of prostate cancer cells through regulation of androgen receptors, the steroid activated proteins that control expression of specific growth relating genes.

In prostate cancer cells whose growth is dependent on testosterone, the predominant male sex steroid, capsaicin reduced cell proliferation in a dose-dependent manner. Increased concentrations of capsaicin caused more prostate cancer cells to freeze in a non-proliferative state, called G0/G1.

Prostate cancer cells that are androgen independent reacted to capsaicin in a similar manner. Capsaicin reduced the amount of androgen receptor that the tumor cells produced, but did not interfere with normal movement of androgen receptor into the nucleus of the cancer cells where the steroid receptor acts to regulate androgen target genes such as prostate specific antigen (PSA). Capsaicin also interfered with the action of androgen receptors even in cells that were modified to produce excess numbers of androgen receptors.

The hot pepper component also reduced cancer cell production of PSA, a protein that often is produced in high quantities by prostate tumors and can signal the presence of prostate cancer in men. PSA content in the blood of men is used as a diagnostic prostate cancer screening measure. PSA is regulated by androgens, and capsaicin limited androgen-induced increases of PSA in the cancer cell lines.

More men in the United States develop prostate cancer than any other type of malignancy. Every year, more than 232,000 new cases of prostate cancer are diagnosed in the U.S., and more than 680,000 develop the disease worldwide. Approximately 30,000 men die from prostate cancer in the U.S. each year, which is about 13 percent of all new cases. Worldwide, there are 221,000 deaths – approximately 31 per cent – among men with prostate cancer.

Lehman conducted the studies in Koeffler’s laboratory in collaboration with UCLA cancer researchers Akio Mori, James O’Kelly, Takishi Kumagai, Julian Desmond, Milena Pervan, and William McBride. Mosahiro Kizaki, a former post-doctoral fellow in Koeffler’s laboratory who initiated the capsaicin studies, is currently at the Keio University School of Medicine, Tokyo, Japan.

###

Related Articles

The mineral selenium proves itself as powerful anti-cancer medicine

Cancer is not a Disease - It's a Survival Mechanism (Book Excerpt)

New research shows vitamin D slashes risk of cancers by 77 percent; cancer industry refuses to support cancer prevention

Mammograms cause breast cancer (and other cancer facts you probably never knew)

Breast Cancer Industry A Scam? Support Education, Not Medication

Popular Topics:

cancer, PSA, prostate cancer, Diabetes, High Blood Pressure, Breast cancer, Prostate cancer, Heart disease, Depression, High cholesterol, Osteoporosis, Vaccines, Autism, ADHD, Infertility, Weight loss, Cancer, Alzheimer's, Trans fats, Acrylamides, Fluoride, Mercury

Take Action: Support NaturalNews.com

Email this article to a friend

Share this article on: NewsVine | digg | del.icio.us

Permalink to this article: http://www.NaturalNews.com/019964.html

Reprinting this article: Non-commercial OK, cite NaturalNews.com with clickable link.

Receive our Natural Health Newsletter for FREE

Subscribe now (it's free!) to win. We randomly choose a subscriber each month to send $100 in eco-home products or a RealGoods.com gift certificate (our choice). Plus, you'll receive FREE news, articles and action alerts from NaturalNews.com editors and join over 800,000 monthly readers who report extraordinary health improvements after becoming a subscriber!
  • Receive breaking news alerts on natural health solutions, renewable energy, the environment, global warming and more.
  • Receive a free instant download of our $29 Secret Sources guide that reveals top sources for little-known health and diet solutions.
Your Email Address:
Free Subscription Code:
Enter the numbers you see:
100% free of charge. Unsubscribe anytime.
Absolutely no spam. We respect your email privacy.

Recommended Special Report:

Seven Words that can Change the World
by Joseph R. Simonetta

Read this special report now...

"Seven Words That Can Change the World reveals the astonishing, simple truths that have the power to forever transform our world for the better while freeing our minds from the enslavement of limiting beliefs. This is not a text for the simple-minded; it is a guiding philosophy for the mindful, intelligent few who are wise enough to seek out -- and recognize -- the higher simplicities of truly purposeful living." - Mike Adams, the Health Ranger, editor of NaturalNews.com

More on NaturalNews.com:

Streaming Health Ranger Videos
CounterThink Cartoons
FREE Special Reports
Podcasts

Also Posted Today

Review: Organic Food Bar Offers Exclusive Discount to Natural News Readers on Their Best Food Bars

Indole-3-Carbinol Nutrient in Broccoli Protects the Heart, Balances Cholesterol

The HPV Vaccine: Herd Immunity or Human Sacrifice?

Lead in Diabecon? An Ayurvedic Anti-Diabetes Herbal Complex Gets the Test

Scientists Agree That EMFs Pose a Threat to Your Health

Beat Disease With Juice Feasting!

NEW 6-CD audio set reveals amazing new protocol for reversing cancer, diabetes, obesity, heart disease and more. Click to learn more.

Own Health Ranger Report Podcasts on Audio CD

Own the first 8 Health Ranger Report audio programs on 6 CDs. Covers weight loss, ADHD, vaccinations, processed meats, bone health and more. Click to learn more.

Featured Videos

Short clip on Aspartame
A short clip on aspartame from the documentary All Jacked Up.
Click here to view now...

Exclusive video on Aspartame
The dangers of aspartame! Exclusive interview footage from Cori Brackett of Sweet Remedy.
Click here to view now...

Exclusive Footage from All Jacked Up!
See interview footage featuring the Health Ranger in the upcoming junk food film, All Jacked Up.
Click here to view now...

Drug Ad Parody
See the Health Ranger's satire parody of Merck's cholesterol drug ad.
Click here to view now...

Free Health Reports!

Amazon Herb Company review
The pH Nutrition Guide to Acid / Alkaline Balance
Pet Food Ingredients Revealed! (shocking)
Medicine From Fish
The Water Cure
The Healing Power of Sunlight and Vitamin D

Featured CounterThink Cartoons

The Plan for the Food Supply


Processed Meat for Christmas


How the Cancer Industry Controls Women


Health Product Companies We Recommend

Read recommendations on supplement companies, health food manufacturers and personal care product makers that you can trust. Our 100% independent review list tells you who to trust and who to avoid in the natural health industry. Click to read.
This site is part of the Natural News Network © 2008 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. Truth Publishing sells no health or nutritional products and earns no money from health product manufacturers or promoters. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.