mice

Exercise, Diet May Protect Against Colorectal Cancer (press release)

Friday, July 07, 2006 by: NaturalNews
Tags: health news, Natural News, nutrition

eTrust Pro Certified

Most Viewed Articles
Popular on Facebook
Biologist explains how marijuana causes tumor cells to commit suicide
Companies begin planting microchips under employees' skin
NJ cops bust teenagers shoveling snow without a permit
Chemotherapy kills cancer patients faster than no treatment at all
U2's Bono partners with Monsanto to destroy African agriculture with GMOs
FDA targets Dr. Bronner's Magic Soaps for sharing health benefits of coconut oil
Italian court rules mercury and aluminum in vaccines cause autism: US media continues total blackout of medical truth
Orthorexia Nervosa - New mental disorder aimed at people who insist on eating a clean diet
Whooping cough outbreak at Massachusetts high school affected only vaccinated students
Inuit Elders tell NASA Earth Axis Shifted
Vaccine flu shots still contain 25 micrograms mercury - 100 times the concentration of 'mercury-loaded' fish
Measles outbreak likely caused by vaccinated children, science shows
Baby formula is loaded with GMOs - Avoid these brands
Extreme trauma from male circumcision causes damage to areas of brain
Terminal stage IV lung cancer patient miraculously cured by cannabis oil
Costco stops selling antibiotic laden chicken in response to consumer demand
FDA cracks down Walmart, GNC, other companies selling supplements that do not contain the herbs on the label
McDonald's french fries found to contain Silly Putty ingredient and petroleum chemical

Delicious
Voluntary exercise and a restricted diet reduced the number and size of pre-cancerous polyps in the intestines of male mice and improved survival, according to a study by a University of Wisconsin-Madison research published May 13 in the journal Carcinogenesis.

The study is the first to suggest that a "negative energy balance" - produced by increasing the mice's energy output by use of a running wheel, while maintaining a restricted calorie intake - appeared to be the important factor in inhibiting the growth of polyps, which are the forerunners of colorectal tumors, says lead author Lisa H. Colbert, assistant professor in the UW-Madison department of kinesiology.

For the study, Colbert and her co-authors used mice with a genetic mutation that predisposed them to develop intestinal polyps.

"Our studies are relevant for humans in that these mice have a mutation in one of the same genes, APC, that is also mutated in human colon cancer," she explains. "The protective effect of exercise and lower body weight in our mice is consistent with epidemiological evidence in humans that suggests higher levels of activity and lower body weight reduces the risk of colon cancer." Mutations in the APC gene in humans are responsible for an inherited condition called familial adenomatous polyposis (FAP). This condition affects about one in 10,000-15,000 people worldwide, and 95 percent of those affected develop polyps in the colon that eventually progress into cancer, usually before age 40.

The researchers randomly assigned seven-week-old male mice to either voluntary wheel running or to no exercise for 10 weeks.

Over the course of the study, the no-exercise control group consumed as much food and water as they wanted. For the first three weeks, the exercising mice received as much as those in the control group. After that, the active mice were restricted to the amount of food and water that the control group received the previous week, which resulted in a negative energy balance.

By the end of the 10 weeks, six of the 23 control mice had died due to the number of polyps that had grown and the resulting anaemia, while all 24 exercising mice were still alive.

"The exercising mice ran an average of 3.8 km a day, and the further they ran the fewer polyps they had. Exercise significantly reduced total polyp number and polyp size, as well as prolonging survival," says Colbert. "On average, there were 16 polyps per mouse in the exercising mice compared to 22 polyps in the control mice - a decrease of 25 percent."

Even though the exercising mice weighed less than those in the control group at the end of the study, they retained more body fat than the non-exercising mice, which Colbert attributes to the fact that the exercising mice were healthier than the non-exercising mice.

The researchers also found that the exercising mice had higher levels of insulin-like growth factor-1 (IGF-1) and corticosterone - hormones associated with the onset of cancer - but saw no correlation with a greater numbers of polyps. Colbert explains, "These data suggest that voluntary exercise that induces a negative energy balance protects against the onset of cancer in these mice, but that the mechanism is unlikely to be related to body composition, IGF-1 or corticosterone."

Another study published in this issue of Carcinogenesis found that exercise can protect against skin cancer.

In this study, female mice that had 24-hour access to running wheels and were exposed to ultraviolet B light (UVB) took longer to develop skin tumors, developed fewer and smaller tumors, and had decreased amounts of body fat compared to mice that did not have access to running wheels. The researchers emphasized that it was unknown yet whether exercise decreased the risk of sunlight-induced skin cancer in humans, and clinical trials were needed to investigate this further.

Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support NaturalNews.com by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite NaturalNews.com with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

GET SHOW DETAILS
+ a FREE GIFT

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.